Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TRAF6 [cytosol]
Stable Identifier
R-SSC-166366
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
TRAF6, A7XUJ6
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Auto-ubiquitination of TRAF6 (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Translocation of TRAF6 to CBM complex (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IRAK1 induces oligomerisation of TRAF6 (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
hp-IRAK1:3xTRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 is K63 poly-ubiquitinated (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Sus scrofa)
hp-IRAK1:3xTRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)
hp-IRAK1:3xTRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Sus scrofa)
hp-IRAK1:3xTRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p62:MEKK3 binds to TRAF6 (Sus scrofa)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
Alpha-protein kinase 1 signaling pathway (Sus scrofa)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Sus scrofa)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MALT1 oligomers (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 oligomer autoubiquitinates (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Sus scrofa)
TRAF6 oligomer [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 oligomerizes (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Sus scrofa)
TRAF6 oligomer [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
Auto-ubiquitination of TRAF6 (Sus scrofa)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Sus scrofa)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Sus scrofa)
TRAF6 oligomer [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Oligomerization of TRAF6 (Sus scrofa)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Sus scrofa)
CBM oligomer:TRAF6 [plasma membrane] (Sus scrofa)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Sus scrofa)
MALT1oligomer:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Sus scrofa)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Sus scrofa)
TRAF6 oligomer [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Sus scrofa)
CBM oligomer:TRAF6 [plasma membrane] (Sus scrofa)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Sus scrofa)
MALT1oligomer:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Pellino ubiquitinates hp-IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IRAK2 mediated activation of TAK1 complex (Sus scrofa)
IRAK2 induces TRAF6 oligomerization (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Pellino ubiquitinates hp-IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IRAK2 mediated activation of TAK1 complex (Sus scrofa)
IRAK2 induces TRAF6 oligomerization (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Pellino ubiquitinates hp-IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IRAK2 mediated activation of TAK1 complex (Sus scrofa)
IRAK2 induces TRAF6 oligomerization (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
IKK complex recruitment mediated by RIP1 (Sus scrofa)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)
RIP1 ubiqutin ligases [cytosol] (Sus scrofa)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Sus scrofa)
Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Pellino ubiquitinates hp-IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IRAK2 mediated activation of TAK1 complex (Sus scrofa)
IRAK2 induces TRAF6 oligomerization (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Pellino ubiquitinates hp-IRAK1 (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IRAK2 mediated activation of TAK1 complex (Sus scrofa)
IRAK2 induces TRAF6 oligomerization (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Deubiquitination (Sus scrofa)
Ovarian tumor domain proteases (Sus scrofa)
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Sus scrofa)
OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Sus scrofa)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Ub-specific processing proteases (Sus scrofa)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
p75 NTR receptor-mediated signalling (Sus scrofa)
Regulated proteolysis of p75NTR (Sus scrofa)
p75NTR ICD signals to NF-kB (Sus scrofa)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p75NTR signals via NF-kB (Sus scrofa)
NF-kB is activated and signals survival (Sus scrofa)
IKKbeta is activated (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p75NTR recruits signalling complexes (Sus scrofa)
IKK-beta is recruited (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
IRAK interacts with TRAF6 (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
MYD88 dissociates (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
TRAF6 is auto-ubiquitinated (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p62 is recruited and forms a complex with TRAF6 (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
p62 recruits an atypical PKC (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A7XUJ6
Gene Names
TRAF6
Reference Genes
BioGPS Gene:396629 TRAF6
ENSEMBL:ENSSSCG00000038082.3 TRAF6
ENSEMBL:ENSSSCG00025053171.1
ENSEMBL:ENSSSCG00040015563.1 TRAF6
ENSEMBL:ENSSSCG00045006364.1 TRAF6
ENSEMBL:ENSSSCG00050051437.1 TRAF6
ENSEMBL:ENSSSCG00055014879.1 TRAF6
ENSEMBL:ENSSSCG00060024340.1 TRAF6
ENSEMBL:ENSSSCG00070001436.1 TRAF6
KEGG Gene (Sus scrofa):396629 TRAF6
Monarch:396629 TRAF6
NCBI Gene:396629 TRAF6
Reference Transcript
RefSeq:XM_013990069.1 TRAF6
RefSeq:XM_005652801.1 TRAF6
RefSeq:NM_001105286.1 TRAF6
Other Identifiers
396629
GO:0000045
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002376
GO:0002637
GO:0002726
GO:0002753
GO:0003824
GO:0004842
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006914
GO:0006955
GO:0007155
GO:0007165
GO:0007249
GO:0009887
GO:0009898
GO:0016567
GO:0016740
GO:0019886
GO:0023052
GO:0030154
GO:0030316
GO:0031234
GO:0031624
GO:0031663
GO:0031666
GO:0032481
GO:0032735
GO:0032743
GO:0032755
GO:0032991
GO:0034142
GO:0034450
GO:0035631
GO:0036211
GO:0038061
GO:0038172
GO:0038173
GO:0042088
GO:0042102
GO:0042475
GO:0042802
GO:0042826
GO:0043011
GO:0043123
GO:0043226
GO:0043422
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046849
GO:0048468
GO:0048471
GO:0048856
GO:0050852
GO:0051865
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:0071345
GO:0097400
GO:0098542
GO:0140096
GO:0140374
GO:1904996
Ssc.6239.1.A1_at
Participates
as a component of
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Sus scrofa)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Sus scrofa)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Sus scrofa)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Sus scrofa)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Sus scrofa)
TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Sus scrofa)
MEKK1:activated TRAF6 [cytosol] (Sus scrofa)
MALT1oligomer:TRAF6 [cytosol] (Sus scrofa)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Sus scrofa)
TRAF6 homotrimer [cytosol] (Sus scrofa)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Sus scrofa)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Sus scrofa)
hp-IRAK1:3xTRAF6 [cytosol] (Sus scrofa)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Sus scrofa)
as an input of
IRAK2 induces TRAF6 oligomerization (Sus scrofa)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)
Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)
Translocation of TRAF6 to CBM complex (Sus scrofa)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)
IRAK interacts with TRAF6 (Sus scrofa)
TRAF6 binds MEKK1 (Sus scrofa)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)
Oligomerization of TRAF6 (Sus scrofa)
TRAF6 binds MALT1 oligomers (Sus scrofa)
TRAF6 oligomerizes (Sus scrofa)
p75NTR ICD signals to NF-kB (Sus scrofa)
p62:MEKK3 binds to TRAF6 (Sus scrofa)
Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)
IRAK1 induces oligomerisation of TRAF6 (Sus scrofa)
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Sus scrofa)
as a repeated unit of
TRAF6 oligomer [cytosol] (Sus scrofa)
Other forms of this molecule
TRAF6 [cytosol]
TRAF6 [cytosol]
TRAF6 [endosome membrane]
TRAF6 [endosome membrane]
TRAF6 [plasma membrane]
TRAF6 [plasma membrane]
TRAF6 [cytosol]
Inferred From
TRAF6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001098756.1
,
XP_013845523.1
,
XP_005652858.1
OpenTargets
ENSG00000175104
IntEnz
2.3.2.27
Ensembl
ENSSSCT00000038108
,
ENSSSCG00000038082
,
ENSSSCP00000034114
VGNC
94365
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text