Reactome | MAP2K4 [cytosol]

MAP2K4 [cytosol]

Stable Identifier

R-SSC-168107

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

MAP2K4, A0A5G2QZR5

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-17 signaling (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated MAPK activation (Sus scrofa)
      - Phosphorylation of MEK4 by MEKK1 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Sus scrofa)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
        
        MAP2K4 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QZR5

Gene Names

MAP2K4

Reference Genes

ENSEMBL:ENSSSCG00000018016.5

UCSC:A0A5G2QZR5 MAP2K4

Other Identifiers

100520100

GO:0000165

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0005524

GO:0006468

GO:0009611

GO:0012501

GO:0016301

GO:0016740

GO:0034390

GO:0035556

GO:0036481

GO:0071260

GO:0140096

GO:2000672

Ssc.22259.1.A1_at

Participates

as an input of

Other forms of this molecule

phospho-MAP2K4 [cytosol]

Inferred From

MAP2K7,MAP2K4 [cytosol] (Homo sapiens)

MAP2K4 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCT00000088197, ENSSSCG00000018016, ENSSSCP00000070388

VGNC

98101