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CHUK:IKBKB:IKBKG [cytosol]
Stable Identifier
R-SSC-168113
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Activation of IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Antiviral mechanism by IFN-stimulated genes (Sus scrofa)
PKR-mediated signaling (Sus scrofa)
IKK complex is activated by PKR (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
NEMO binds polyubiquitinated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
Phosphorylation of IKK-beta by TAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
IKK complex recruitment mediated by RIP1 (Sus scrofa)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TNFR1-induced NF-kappa-B signaling pathway (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CHUK [cytosol]
(Sus scrofa)
IKBKB [cytosol]
(Sus scrofa)
IKBKG [cytosol]
(Sus scrofa)
Participates
as an input of
IKK complex is activated by PKR (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)
GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Sus scrofa)
NEMO binds polyubiquitinated IRAK1 (Sus scrofa)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)
Activation of IKK complex (Sus scrofa)
Phosphorylation of IKK-beta by TAK1 (Sus scrofa)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
as a component of
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Sus scrofa)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Sus scrofa)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
as an output of
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
Inferred From
CHUK:IKBKB:IKBKG [cytosol]
(Homo sapiens)
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