Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
APOA1 [extracellular region]
Stable Identifier
R-SSC-174720
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
extracellular region
Synonyms
APOA1(25-266), A0A286ZQC7
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Heme signaling (Sus scrofa)
FeHM oxidises LDL,HDL (Sus scrofa)
LDL,HDL [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
oxidized LDL,HDL [extracellular region] (Sus scrofa)
oxidized discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
oxidized spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Response to elevated platelet cytosolic Ca2+ (Sus scrofa)
Platelet degranulation (Sus scrofa)
Release of platelet secretory granule components (Sus scrofa)
Platelet releasate secretory granule proteins [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Metabolism (Sus scrofa)
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of fat-soluble vitamins (Sus scrofa)
Retinoid metabolism and transport (Sus scrofa)
CR:atREs binds apoE and HSPG (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
CR:atREs:HSPG:apoE [plasma membrane] (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Cytosolic CMs translocate to extracellular region (Sus scrofa)
nascent CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LPL hydrolyses TGs from mature CMs (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
mature CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Sus scrofa)
CR:atREs:HSPG:apoE [plasma membrane] (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Nascent CMs transform into mature CMs (Sus scrofa)
mature CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
nascent CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Sensory Perception (Sus scrofa)
Visual phototransduction (Sus scrofa)
Retinoid metabolism and transport (Sus scrofa)
CR:atREs binds apoE and HSPG (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
CR:atREs:HSPG:apoE [plasma membrane] (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Cytosolic CMs translocate to extracellular region (Sus scrofa)
nascent CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LPL hydrolyses TGs from mature CMs (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
mature CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Sus scrofa)
CR:atREs:HSPG:apoE [plasma membrane] (Sus scrofa)
CR:atREs [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Nascent CMs transform into mature CMs (Sus scrofa)
mature CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
nascent CM:atREs [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Transport of small molecules (Sus scrofa)
Plasma lipoprotein assembly, remodeling, and clearance (Sus scrofa)
Plasma lipoprotein assembly (Sus scrofa)
Chylomicron assembly (Sus scrofa)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Sus scrofa)
chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
nascent chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Sus scrofa)
nascent chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
HDL assembly (Sus scrofa)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
pre-beta HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Plasma lipoprotein clearance (Sus scrofa)
HDL clearance (Sus scrofa)
Disassembly of SR-BI-bound spherical HDL (Sus scrofa)
pre-beta HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
HDLBP binds HDL (Sus scrofa)
HDLBP:HDL [plasma membrane] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL and SR-BI receptor form a complex at the cell surface (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Plasma lipoprotein remodeling (Sus scrofa)
Chylomicron remodeling (Sus scrofa)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
chylomicron [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
HDL remodeling (Sus scrofa)
Discoidal HDL binds membrane-associated free cholesterol (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
discoidal HDL:cholesterol [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Sus scrofa)
LCAT:discoidal HDL complex [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Sus scrofa)
LCAT:spherical HDL complex [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Sus scrofa)
LCAT:discoidal HDL complex [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
LCAT:spherical HDL complex <=> LCAT + spherical HDL (Sus scrofa)
LCAT:spherical HDL complex [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Spherical HDL binds C and E apolipoproteins (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Spherical HDL binds membrane-associated free cholesterol and phospholipids (Sus scrofa)
enlarged spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Vesicle-mediated transport (Sus scrofa)
Binding and Uptake of Ligands by Scavenger Receptors (Sus scrofa)
Scavenging by Class A Receptors (Sus scrofa)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)
MSR1:Ligand [plasma membrane] (Sus scrofa)
Ligands of MSR1 [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Scavenging by Class B Receptors (Sus scrofa)
Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)
Platelet glycoprotein IV:Ligand [plasma membrane] (Sus scrofa)
Ligands of CD36 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
SCARB1 (SR-BI, CLA-1) binds ligands (Sus scrofa)
Ligands of SCARB1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
SCARB1:Ligand [plasma membrane] (Sus scrofa)
Ligands of SCARB1 [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Scavenging of heme from plasma (Sus scrofa)
Haptoglobin-related Protein binds Hemoglobin (Sus scrofa)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
Hemoglobin:HPR:APOL1:APOA1:HDL3 [extracellular region] (Sus scrofa)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Sus scrofa)
APOA1 [extracellular region] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A286ZQC7
Gene Names
APOA1
Reference Genes
ENSEMBL:ENSSSCG00000030921.4
Other Identifiers
397691
GO:0001540
GO:0001932
GO:0001935
GO:0002376
GO:0002719
GO:0005102
GO:0005215
GO:0005319
GO:0005543
GO:0005576
GO:0005615
GO:0006629
GO:0006644
GO:0006656
GO:0006695
GO:0006869
GO:0006954
GO:0007010
GO:0007155
GO:0007186
GO:0007229
GO:0008035
GO:0008202
GO:0008203
GO:0008211
GO:0008289
GO:0010804
GO:0010875
GO:0010903
GO:0015485
GO:0016192
GO:0019899
GO:0019915
GO:0022600
GO:0023052
GO:0030139
GO:0030300
GO:0030301
GO:0030325
GO:0031072
GO:0031410
GO:0032489
GO:0032691
GO:0033344
GO:0033700
GO:0034115
GO:0034190
GO:0034191
GO:0034361
GO:0034364
GO:0034366
GO:0034375
GO:0034380
GO:0035025
GO:0036211
GO:0042157
GO:0042158
GO:0042632
GO:0042802
GO:0043226
GO:0043534
GO:0043691
GO:0045499
GO:0046470
GO:0048018
GO:0048856
GO:0048870
GO:0050728
GO:0050766
GO:0050821
GO:0050919
GO:0051180
GO:0051496
GO:0055091
GO:0060228
GO:0060354
GO:0060761
GO:0061024
GO:0065003
GO:0070328
GO:0070508
GO:0070653
GO:0071813
GO:0090205
GO:0098772
GO:0120009
GO:0120020
GO:1900026
GO:1902995
Ssc.807.1.S1_at
Participates
as a member of
Platelet releasate secretory granule proteins [extracellular region] (Sus scrofa)
Ligands of MSR1 [extracellular region] (Sus scrofa)
as a component of
nascent CM:atREs [extracellular region] (Sus scrofa)
mature CM:atREs [extracellular region] (Sus scrofa)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Sus scrofa)
TG-depleted chylomicron [extracellular region] (Sus scrofa)
enlarged spherical HDL [extracellular region] (Sus scrofa)
chylomicron [extracellular region] (Sus scrofa)
nascent chylomicron [extracellular region] (Sus scrofa)
pre-beta HDL [extracellular region] (Sus scrofa)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Sus scrofa)
oxidized spherical HDL [extracellular region] (Sus scrofa)
oxidized discoidal HDL [extracellular region] (Sus scrofa)
discoidal HDL [extracellular region] (Sus scrofa)
spherical HDL [extracellular region] (Sus scrofa)
as an input of
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)
as an output of
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Sus scrofa)
This entity regulates
Positively
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
(Sus scrofa)
Other forms of this molecule
APOA1 [secretory granule lumen]
APOA1 [cytosol]
APOA1 [early endosome]
APOA1 [endoplasmic reticulum lumen]
APOA1 [extracellular region]
APOA1 [plasma membrane]
APOA1 [endocytic vesicle lumen]
phospho-APOA1 [endoplasmic reticulum lumen]
APOA1 [endoplasmic reticulum lumen]
Inferred From
APOA1(25-266) [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000118137
Ensembl
ENSSSCT00000053994
,
ENSSSCG00000030921
,
ENSSSCP00000033805
VGNC
85415
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text