Reactome | Histone H2A [nucleoplasm]

Cell Cycle (Sus scrofa)

- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Prophase (Sus scrofa)
      - Condensation of Prophase Chromosomes (Sus scrofa)
        
        CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PHF8 demethylates histone H4K20me1 (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PLK1 binds phosphorylated condensin II complex (Sus scrofa)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)
        
        Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        SETD8 monomethylates histone H4 (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
- Chromosome Maintenance (Sus scrofa)
  - Nucleosome assembly (Sus scrofa)
    - Deposition of new CENPA-containing nucleosomes at the centromere (Sus scrofa)
      - RSF complex binds the centromere (Sus scrofa)
        
        CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Sus scrofa)
        
        Centromeric Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Sus scrofa)
        
        Centromeric Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
  - Telomere Maintenance (Sus scrofa)
    - Inhibition of DNA recombination at telomere (Sus scrofa)
      - ATRX:DAXX binds to subtelomeric chromosomal regions (Sus scrofa)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Sus scrofa)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - DNA Damage/Telomere Stress Induced Senescence (Sus scrofa)
      - Telomere shortening during replicative exhaustion (Sus scrofa)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - Oxidative Stress Induced Senescence (Sus scrofa)
      - KDM6B demethylates H3K27me3 on p16INK4A promoter (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        CDKN2A Gene:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        CDKN2A Gene:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - Senescence-Associated Secretory Phenotype (SASP) (Sus scrofa)
      - EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)
        
        IL6 gene:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        IL6 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)
        
        IL8 gene:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        IL8 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)

Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - RMTs methylate histone arginines (Sus scrofa)
    - PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)
      - Histone H2A [nucleoplasm] (Sus scrofa)

DNA Repair (Sus scrofa)

- Base Excision Repair (Sus scrofa)
  - Base-Excision Repair, AP Site Formation (Sus scrofa)
    - Depurination (Sus scrofa)
      - Cleavage of the damaged purine (Sus scrofa)
        
        NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Sus scrofa)
        
        NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Sus scrofa)
        
        AP-Telomeric DNA:Shelterin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Sus scrofa)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - Recognition and association of DNA glycosylase with site containing an affected purine (Sus scrofa)
        
        NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Sus scrofa)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Sus scrofa)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Assembly of the pre-replicative complex (Sus scrofa)
    - Assembly of the ORC complex at the origin of replication (Sus scrofa)
      - ORC1 binds to H4K20me2 (Sus scrofa)
        
        H4K20Me2-nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Sus scrofa)
        
        H4K20Me2-nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- Epigenetic regulation of gene expression (Sus scrofa)
  - Negative epigenetic regulation of rRNA expression (Sus scrofa)
    - NoRC negatively regulates rRNA expression (Sus scrofa)
      - MBD2 binds methylcytosine in chromatin (Sus scrofa)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - SIRT1 negatively regulates rRNA expression (Sus scrofa)
      - Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - eNoSC deacetylates histone H3 (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Chromatin with acetylated H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome (H3K9ac, H3K14ac) [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
  - PRC2 methylates histones and DNA (Sus scrofa)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Sus scrofa)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Sus scrofa)
        
        Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 Core:Chromatin [nucleoplasm] (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - PRC2 recruits DNA methyltransferases (Sus scrofa)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 Core:Chromatin [nucleoplasm] (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - PRC2 Core:Chromatin [nucleoplasm] (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Sus scrofa)
        
        Chromatin with trimethylated H3K27 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Sus scrofa)
      - Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
  - Positive epigenetic regulation of rRNA expression (Sus scrofa)
    - B-WICH complex positively regulates rRNA expression (Sus scrofa)
      - B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Sus scrofa)
        
        Nucleosome (H3K9ac) [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
  - Regulation of endogenous retroelements (Sus scrofa)
    - Regulation of endogenous retroelements by KRAB-ZFP proteins (Sus scrofa)
      - SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Sus scrofa)
        
        ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Sus scrofa)
        
        KRAB-ZFP:retroelement chromatin [nucleoplasm] (Sus scrofa)
        
        Retroelement chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Retroelement chromatin with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Sus scrofa)
      - SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
- Gene Silencing by RNA (Sus scrofa)
  - Transcriptional regulation by small RNAs (Sus scrofa)
    - AGO1,2:small RNA complexes interact with chromatin (Sus scrofa)
      - AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm] (Sus scrofa)
        
        Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - Chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Promoter Escape (Sus scrofa)
      - Elongation of pre-rRNA transcript (Sus scrofa)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase I Promoter Opening (Sus scrofa)
      - UBF-1 Binds rDNA Promoter (Sus scrofa)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional regulation by RUNX1 (Sus scrofa)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Nuclear Receptors (Sus scrofa)
  - ESR-mediated signaling (Sus scrofa)
    - Estrogen-dependent gene expression (Sus scrofa)
      - Binding of AP1 transcriptional activator complexes to CCND1 promoter (Sus scrofa)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Sus scrofa)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - FOXA1 and GATA3 bind to CCND1 promoter (Sus scrofa)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Sus scrofa)
        
        GREB1 gene:nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm] (Sus scrofa)
        
        GREB1 gene:nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
      - Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        MYC gene, BCL2 gene: H3K9me2 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
  - Signaling by Rho GTPases (Sus scrofa)
    - RHO GTPase Effectors (Sus scrofa)
      - RHO GTPases activate PKNs (Sus scrofa)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Sus scrofa)
        
        Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        Demethylase KDM4C binds KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        Histone H2A [nucleoplasm] (Sus scrofa)