Reactome | PDGFA [extracellular region]

PDGFA [extracellular region]

Stable Identifier

R-SSC-184199

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

PDGFA-1, A0A8W4FMH5

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
        
        RAS GEFs [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by PDGF (Sus scrofa)
    - Autophosphorylation of PDGF alpha receptors (Sus scrofa)
      - PDGF alpha receptor: PDGF dimers [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
        
        PDGF alpha receptor: PDGF dimers [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
    - Downstream signal transduction (Sus scrofa)
      - Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - Activation of Src (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - Crk binds to the active PDGF receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - GRB2:SOS1 complex binds to the active receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - Grb7 binds to the active PDGF receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - Nck binds to the active PDGF receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - PI3-kinase binds to the active receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - PLC-gamma binds to the active receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - Phosphorylation of PLCgamma by PDGFR (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - SH2 domain of Src binds to the active receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - SHP2 binds to the active receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - STAT binds to the active receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
    - PDGF binds to extracellular matrix proteins (Sus scrofa)
      - PDGF A and B chains with retention motif [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - PDGF A and B chains:ECM complex [extracellular region] (Sus scrofa)
        
        PDGF A and B chains with retention motif [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
    - PDGF dimer binds two receptors simultaneously (Sus scrofa)
      - Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - PDGF:PDGF receptor dimer [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
    - PDGF-AA clevage by Furin (Sus scrofa)
      - active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
    - PDGFRs bind type I TKI (Sus scrofa)
      - PDGF alpha receptor: PDGF dimers [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)
      - PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
        
        PDGF alpha receptor: PDGF dimers [plasma membrane] (Sus scrofa)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Sus scrofa)
        
        active PDGF-AA dimer [extracellular region] (Sus scrofa)
        
        PDGFA [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A8W4FMH5

Gene Names

PDGFA

Reference Genes

BioGPS Gene:100519764 PDGFA

ENSEMBL:ENSSSCG00000007541.5

KEGG Gene (Sus scrofa):100519764 PDGFA

Monarch:100519764 PDGFA

NCBI Gene:100519764 PDGFA

Reference Transcript

RefSeq:XM_013987660.1 PDGFA

Other Identifiers

100519764

GO:0005161

GO:0005518

GO:0005576

GO:0005615

GO:0006629

GO:0008083

GO:0008284

GO:0009611

GO:0009986

GO:0010512

GO:0010544

GO:0014910

GO:0016020

GO:0023052

GO:0030335

GO:0031954

GO:0035793

GO:0036211

GO:0042060

GO:0042803

GO:0043410

GO:0046982

GO:0048008

GO:0048018

GO:0048146

GO:0048407

GO:0048856

GO:0048870

GO:0050919

GO:0051781

GO:0051897

GO:0070374

GO:0098772

GO:1990265

Ssc.6173.3.S1_a_at

Participates

as a component of

as a member of

PDGF A and B chains with retention motif [extracellular region] (Sus scrofa)

Other forms of this molecule

PDGFA [platelet alpha granule lumen]

PDGFA [endoplasmic reticulum lumen]

PDGFA [Golgi lumen]

PDGFA [Golgi membrane]

PDGFA [extracellular region]

Inferred From

Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)

PDGFA-1 [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_013843114.1

OpenTargets

ENSG00000197461

Ensembl

ENSSSCT00000092944, ENSSSCG00000007541, ENSSSCP00000080551

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