Reactome | NFKB1(1-433):RELA [cytosol]

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to mechanical stimuli (Sus scrofa)
  - Response of endothelial cells to shear stress (Sus scrofa)
    - Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Sus scrofa)
      - PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Sus scrofa)
        
        IkB(alpha):NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Signaling by the B Cell Receptor (BCR) (Sus scrofa)
    - Downstream signaling events of B Cell Receptor (BCR) (Sus scrofa)
      - Activation of NF-kappaB in B cells (Sus scrofa)
        
        Activated IKK phosphorylates I-kappaB (Sus scrofa)
        
        NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Sus scrofa)
        
        NF-kappaB p50:p65:IKB [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Sus scrofa)
        
        NF-kappaB p50:p65:p-IKB [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)
        
        NF-kappaB p50,p65,c-Rel dimer [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        Ubiquitinated IkB is degraded (Sus scrofa)
        
        NF-kappaB p50,p65,c-Rel dimer [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Sus scrofa)
        
        NF-kappaB p50:p65:ub-p-IKB [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
  - TCR signaling (Sus scrofa)
    - Downstream TCR signaling (Sus scrofa)
      - 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
        
        K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
      - NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
      - p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)
        
        IkB(alpha):NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-1 signaling (Sus scrofa)
        
        NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - C-type lectin receptors (CLRs) (Sus scrofa)
    - CLEC7A (Dectin-1) signaling (Sus scrofa)
      - 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
        
        K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
      - NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
      - p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)
        
        IkB(alpha):NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated NF-kB activation (Sus scrofa)
      - 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
        
        K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
      - NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
      - p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)
        
        IkB(alpha):NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Death Receptor Signaling (Sus scrofa)
  - p75 NTR receptor-mediated signalling (Sus scrofa)
    - Regulated proteolysis of p75NTR (Sus scrofa)
      - p75NTR ICD signals to NF-kB (Sus scrofa)
        
        NF-kB:p75NTR ICD:TRAF6 [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
    - p75NTR signals via NF-kB (Sus scrofa)
      - NF-kB is activated and signals survival (Sus scrofa)
        
        IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)
        
        IkB(alpha):NF-kB complex [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)
        
        NF-kB migrates to the nucleus and turns on transcription (Sus scrofa)
        
        NFKB1(1-433):RELA [cytosol] (Sus scrofa)