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VAV1 [cytosol]
Stable Identifier
R-SSC-195066
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
VAV1, A0A286ZQX2
Locations in the PathwayBrowser
Expand all
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)
PIP3:VAV1,2,3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
VAV family:PIP2 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
p-SLP-76 binds VAV (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
p-SLP-76:VAV [cytosol] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Costimulation by the CD28 family (Sus scrofa)
CD28 co-stimulation (Sus scrofa)
CD28 dependent Vav1 pathway (Sus scrofa)
Activation of Vav1 (Sus scrofa)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Translocation of Vav1 to CD28 (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
BTK binds BTK inhibitors (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
BTK:BTK inhibitors [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)
TEC:VAV1 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Regulation of signaling by CBL (Sus scrofa)
CBL binds VAV (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Autophosphorylation of BTK/ITK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
FCERI mediated MAPK activation (Sus scrofa)
Phosphorylation and activation of VAV (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Recruitment of VAV to p-SLP-76 (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
Phosphorylation of VAV (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
p75 NTR receptor-mediated signalling (Sus scrofa)
Cell death signalling via NRAGE, NRIF and NADE (Sus scrofa)
NRAGE signals death through JNK (Sus scrofa)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)
GEFs [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Signaling by Erythropoietin (Sus scrofa)
Erythropoietin activates RAS (Sus scrofa)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Sus scrofa)
GRB2-1:VAV1 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
GRB2-1:VAV1 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (12/13) signalling events (Sus scrofa)
GEFs activate RhoA,B,C (Sus scrofa)
GEFs [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by SCF-KIT (Sus scrofa)
Phosphorylation and activation of VAV1 (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
Src kinases phosphorylate VAV (Sus scrofa)
PIP3:VAV1,2,3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase cycle (Sus scrofa)
RAC1 GTPase cycle (Sus scrofa)
RAC1 GEFs activate RAC1 (Sus scrofa)
RAC1 GEFs [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
RAC2 GTPase cycle (Sus scrofa)
RAC2 GEFs activate RAC2 (Sus scrofa)
RAC2 GEFs [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
RHOA GTPase cycle (Sus scrofa)
RHOA GEFs activate RHOA (Sus scrofa)
RHOA GEFs [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
RHOG GTPase cycle (Sus scrofa)
RHOG GEFs activate RHOG (Sus scrofa)
RHOG GEFs [cytosol] (Sus scrofa)
VAV1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A286ZQX2
Gene Names
VAV1
Reference Genes
ENSEMBL:ENSSSCG00000013553.4
Other Identifiers
100519821
GO:0001784
GO:0002376
GO:0005085
GO:0005737
GO:0005911
GO:0006909
GO:0006955
GO:0007155
GO:0007166
GO:0007186
GO:0007229
GO:0008361
GO:0016192
GO:0016477
GO:0023052
GO:0030154
GO:0030217
GO:0030593
GO:0035556
GO:0042110
GO:0045785
GO:0045954
GO:0046872
GO:0048856
GO:0048870
GO:0072593
GO:0098542
GO:0098772
GO:0140031
Ssc.5910.1.A1_at
Ssc.5910.3.S1_at
Participates
as a component of
GRB2-1:VAV1 [cytosol] (Sus scrofa)
TEC:VAV1 [cytosol] (Sus scrofa)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Sus scrofa)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
as a member of
RHOA GEFs [cytosol] (Sus scrofa)
RAC2 GEFs [cytosol] (Sus scrofa)
RAC1 GEFs [cytosol] (Sus scrofa)
RHOG GEFs [cytosol] (Sus scrofa)
GEFs [cytosol] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
as an input of
Phosphorylation and activation of VAV1 (Sus scrofa)
IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)
CBL binds VAV (Sus scrofa)
Translocation of Vav1 to CD28 (Sus scrofa)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
Other forms of this molecule
phospho-VAV1 [plasma membrane]
phospho-VAV1 [cytosol]
VAV1 [plasma membrane]
Inferred From
VAV1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000141968
Ensembl
ENSSSCP00000033977
,
ENSSSCT00000039776
,
ENSSSCG00000013553
VGNC
94807
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