Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-IRS2 [plasma membrane]
Stable Identifier
R-SSC-198334
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
plasma membrane
Synonyms
p-Y-IRS2, A0A287B726
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
Phospho-IRS1/2 (by TRKA) [plasma membrane] (Sus scrofa)
phospho-IRS2 [plasma membrane] (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
Phospho-IRS1/2 (by TRKA) [plasma membrane] (Sus scrofa)
phospho-IRS2 [plasma membrane] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK1 (TRKA) (Sus scrofa)
PI3K/AKT activation (Sus scrofa)
PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
Phospho-IRS1/2 (by TRKA) [plasma membrane] (Sus scrofa)
phospho-IRS2 [plasma membrane] (Sus scrofa)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
IGF1R signaling cascade (Sus scrofa)
IRS-related events triggered by IGF1R (Sus scrofa)
IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Sus scrofa)
IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Sus scrofa)
p-IRS1,2,4 [plasma membrane] (Sus scrofa)
phospho-IRS2 [plasma membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287B726
Gene Names
IRS2
Reference Genes
ENSEMBL:ENSSSCG00000034763.2
Other Identifiers
110255858
GO:0002053
GO:0002376
GO:0002903
GO:0005068
GO:0005158
GO:0005829
GO:0005886
GO:0005975
GO:0006091
GO:0006629
GO:0007420
GO:0008283
GO:0008284
GO:0008286
GO:0009749
GO:0010631
GO:0010634
GO:0010748
GO:0010907
GO:0012501
GO:0016477
GO:0019901
GO:0023052
GO:0030674
GO:0030879
GO:0030890
GO:0032000
GO:0032024
GO:0032869
GO:0043548
GO:0044342
GO:0045725
GO:0046326
GO:0048856
GO:0048870
GO:0051897
GO:0055085
GO:0060090
GO:0141038
GO:1904692
Ssc.24696.1.S1_at
Ssc.24696.2.S1_at
Participates
as a member of
p-IRS1,2,4 [plasma membrane] (Sus scrofa)
Phospho-IRS1/2 (by TRKA) [plasma membrane] (Sus scrofa)
Other forms of this molecule
IRS2 [plasma membrane]
IRS2 [cytosol]
phospho-IRS2 [cytosol]
Inferred From
p-Y-IRS2 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000185950
Ensembl
ENSSSCT00000043241
,
ENSSSCP00000052323
,
ENSSSCG00000034763
VGNC
89214
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text