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PLCG1 [cytosol]
Stable Identifier
R-SSC-202320
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
PLCG1, F1SDV6
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Nervous system development (Sus scrofa)
Axon guidance (Sus scrofa)
RET signaling (Sus scrofa)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)
2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Hemostasis (Sus scrofa)
Cell surface interactions at the vascular wall (Sus scrofa)
PECAM1 interactions (Sus scrofa)
Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)
PECAM-1:PLC gamma1 complex [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
TCR signaling (Sus scrofa)
Generation of second messenger molecules (Sus scrofa)
Phosphorylation of PLC-gamma1 (Sus scrofa)
PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Sus scrofa)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
PLCG1:p-5Y-LAT [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of PLC-gamma1 to LAT (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
PLCG1:p-5Y-LAT [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Antiviral mechanism by IFN-stimulated genes (Sus scrofa)
ISG15 antiviral mechanism (Sus scrofa)
ISGylation of host proteins (Sus scrofa)
ISG15 targets [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
ISGylated host proteins [cytosol] (Sus scrofa)
ISG15 targets [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Sus scrofa)
ISG15 targets [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
ISGylated host proteins [cytosol] (Sus scrofa)
ISG15 targets [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
DAP12 interactions (Sus scrofa)
DAP12 signaling (Sus scrofa)
Activation of RAC1 by VAV2/3 (Sus scrofa)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phosphorylation of BTK by p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-SYK/p-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Autophosphorylation of BTK/ITK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
FCERI mediated MAPK activation (Sus scrofa)
Activation of RAC1 by VAV (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Autophosphorylation of PAK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phosphorylation and activation of VAV (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of VAV to p-SLP-76 (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Role of phospholipids in phagocytosis (Sus scrofa)
Phosphorylation and activation of PLCG (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Recruitment of PLCgamma to membrane (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by EGFR (Sus scrofa)
EGFR interacts with phospholipase C-gamma (Sus scrofa)
EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
VEGFR2 mediated cell proliferation (Sus scrofa)
SFKs phosphorylate PLCG1 (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] (Sus scrofa)
PLCG1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1SDV6
Gene Names
PLCG1
Reference Genes
ENSEMBL:ENSSSCG00000007356.5
UCSC:F1SDV6 PLCG1
Other Identifiers
100152497
GO:0001701
GO:0001726
GO:0002376
GO:0003824
GO:0004435
GO:0004629
GO:0005168
GO:0005509
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006629
GO:0007165
GO:0007173
GO:0008081
GO:0008180
GO:0009395
GO:0010634
GO:0012501
GO:0016042
GO:0016477
GO:0016787
GO:0019722
GO:0019901
GO:0023052
GO:0030027
GO:0030971
GO:0032587
GO:0035254
GO:0035556
GO:0042995
GO:0043226
GO:0043536
GO:0045766
GO:0046872
GO:0048856
GO:0048870
GO:0050804
GO:0050852
GO:0050896
GO:0051281
GO:0055065
GO:0055085
GO:0071364
GO:0098685
GO:0098978
GO:1905564
GO:2000353
Ssc.11206.1.A1_at
Participates
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)
Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)
Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)
Recruitment of PLC-gamma1 to LAT (Sus scrofa)
p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)
Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Sus scrofa)
PECAM-1:PLC gamma1 complex [plasma membrane] (Sus scrofa)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Sus scrofa)
PLCG1:p-5Y-LAT [plasma membrane] (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Sus scrofa)
as a member of
ISG15 targets [cytosol] (Sus scrofa)
PLC gamma1,2 [cytosol] (Sus scrofa)
Other forms of this molecule
phospho-PLCG1 [plasma membrane]
phospho-PLCG1 [cytosol]
PLCG1 [plasma membrane]
phospho-PLCG1 [plasma membrane]
Inferred From
PLCG1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSSSCP00000007834
,
ENSSSCT00000008048
,
ENSSSCG00000007356
VGNC
96492
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.524
2
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