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CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
Stable Identifier
R-SSC-202513
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Downstream signaling events of B Cell Receptor (BCR) (Sus scrofa)
Activation of NF-kappaB in B cells (Sus scrofa)
Activated IKK phosphorylates I-kappaB (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Activation of IKK complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Interleukin-17 signaling (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
Phosphorylation of IKK-beta by TAK1 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
SLC15A4:TASL-dependent IRF5 activation (Sus scrofa)
Activated IKBKB phosphorylates IRF5 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
SLC15A4:TASL-dependent IRF5 activation (Sus scrofa)
Activated IKBKB phosphorylates IRF5 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CHUK [cytosol]
(Sus scrofa)
IKBKG [cytosol]
(Sus scrofa)
phospho-IKBKB [cytosol]
(Sus scrofa)
Participates
as an input of
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
as an output of
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)
Activation of IKK complex (Sus scrofa)
Phosphorylation of IKK-beta by TAK1 (Sus scrofa)
Inferred From
Active IKK complex [cytosol]
(Homo sapiens)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
(Homo sapiens)
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