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MDK [extracellular region]
Stable Identifier
R-SSC-2160953
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
extracellular region
Synonyms
MDK, A0A287BRY9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
ALK autophosphorylation (Sus scrofa)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
MDK:ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
MDK:ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK binds JAK3 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK binds PLCG1 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:PLCG1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK binds SHC1 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:SHC1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK dimer binds IRS1 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:IRS1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK phosphorylates IRS1 (Sus scrofa)
Active ALK:IRS1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:pY-IRS1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK phosphorylates JAK3 (Sus scrofa)
Active ALK:JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:p-Y980 JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK phosphorylates PLCG1 (Sus scrofa)
Active ALK:PLCG1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:p-4Y PLCG1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK phosphorylates SHC1 (Sus scrofa)
Active ALK:SHC1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:p-3Y SHC1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK recruits PI3K (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:PI3K [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Liganded-ALK dimer binds type I ALK-binding TKIs (Sus scrofa)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
MDK:ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
MDK:ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
MDK and PTN in ALK signaling (Sus scrofa)
(PTN,MDK):PTPRZ oligomerizes (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
ALK binds ligand midkine (MDK) (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
MDK:ALK [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
PTN and MDK bind to PTPRZ (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)
(PTN,MDK):ALK dimer [plasma membrane] (Sus scrofa)
MDK:ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
Active ALK:PI3K [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
PTPN6 dephosphorylates JAK3 (Sus scrofa)
Active ALK:JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
Active ALK:p-Y980 JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
STAT3 is phosphorylated downstream of active ALK (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287BRY9
Gene Names
MDK
Reference Genes
ENSEMBL:ENSSSCG00000013260.5
Other Identifiers
100359358
GO:0001662
GO:0002232
GO:0002286
GO:0002376
GO:0002690
GO:0005576
GO:0006351
GO:0006355
GO:0006954
GO:0007010
GO:0007155
GO:0007162
GO:0007614
GO:0008083
GO:0008201
GO:0009611
GO:0010667
GO:0010718
GO:0010759
GO:0010838
GO:0010976
GO:0010996
GO:0012501
GO:0016020
GO:0021542
GO:0021681
GO:0021766
GO:0021987
GO:0022414
GO:0022600
GO:0023052
GO:0030154
GO:0030279
GO:0030335
GO:0030421
GO:0032330
GO:0032735
GO:0035374
GO:0035556
GO:0042246
GO:0043524
GO:0044849
GO:0045582
GO:0045590
GO:0045785
GO:0045893
GO:0046850
GO:0048018
GO:0048477
GO:0048714
GO:0048856
GO:0048870
GO:0050729
GO:0050795
GO:0050877
GO:0050896
GO:0051781
GO:0061036
GO:0071673
GO:0090023
GO:0090090
GO:0098772
GO:0106015
GO:0106016
GO:0106091
GO:1900026
GO:1903039
GO:1904036
GO:1904399
GO:1904996
GO:1905555
GO:1905564
GO:1905653
GO:2000179
GO:2000347
GO:2000391
GO:2001224
Ssc.20489.1.S1_at
Ssc.20489.1.S1_s_at
Participates
as a member of
PTN,MDK [extracellular region] (Sus scrofa)
as a component of
MDK:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
MDK:ALK [plasma membrane] (Sus scrofa)
MDK:ALK dimer [plasma membrane] (Sus scrofa)
MDK [extracellular region] (Sus scrofa)
as an input of
ALK binds ligand midkine (MDK) (Sus scrofa)
Inferred From
MDK [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000110492
Ensembl
ENSSSCT00000046360
,
ENSSSCP00000059415
,
ENSSSCG00000013260
VGNC
100167
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