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FYN,LCK [cytosol]
Stable Identifier
R-SSC-2395419
Type
Set [DefinedSet]
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-stimulation by CD28 (Sus scrofa)
CD28 dependent PI3K/Akt signaling (Sus scrofa)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
CD28:PI3K [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
PI3K binds CD28 (Sus scrofa)
CD28:PI3K [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
CD28 dependent Vav1 pathway (Sus scrofa)
Activation of Cdc42 by pVav1 (Sus scrofa)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
CD28:Grb2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Activation of Rac1 by pVav1 (Sus scrofa)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
CD28:Grb2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Activation of Vav1 (Sus scrofa)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
CD28:Grb2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
CD28:Grb2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Grb2 binds CD28 (Sus scrofa)
CD28:Grb2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Translocation of Vav1 to CD28 (Sus scrofa)
CD28:Grb2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
CD28:Grb2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Gads binds CD28 (Sus scrofa)
CD28:GRAP2 [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Phosphorylation of CD28 (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
DAP12 interactions (Sus scrofa)
DAP12 signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Phosphorylation of BTK by p-SYK (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Phosphorylation of LAT by p-SYK (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
p-SYK/p-BTK [plasma membrane] (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Phosphorylation of SYK (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Recruitment of SYK to p-DAP12 (Sus scrofa)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
CD28:PI3K [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
CD28:PI3K [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
FYN,LCK [cytosol] (Sus scrofa)
Participants
members
FYN [cytosol]
(Sus scrofa)
LCK [cytosol]
(Sus scrofa)
Participates
as an input of
Phosphorylation of CD28 (Sus scrofa)
as a component of
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
Inferred From
FYN,LCK [cytosol]
(Homo sapiens)
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