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active caspase-8 [cytosol]
Stable Identifier
R-SSC-2562550
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
CLEC7A/inflammasome pathway (Sus scrofa)
ASC binds Caspase-8 complex (Sus scrofa)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Sus scrofa)
MALT1:active caspase-8 [cytosol] (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
MALT1:active caspase-8 [cytosol] (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Caspase-8 binds MALT (Sus scrofa)
MALT1:active caspase-8 [cytosol] (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Caspase-8 cleaves IL1B precursor (Sus scrofa)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Sus scrofa)
MALT1:active caspase-8 [cytosol] (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
TRIF-mediated programmed cell death (Sus scrofa)
Caspase-8 processing within TLR4 complex (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
N4BP1 binds IKBKG (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Programmed Cell Death (Sus scrofa)
Apoptosis (Sus scrofa)
Apoptotic execution phase (Sus scrofa)
Apoptotic cleavage of cellular proteins (Sus scrofa)
Caspase-mediated cleavage of cytoskeletal proteins (Sus scrofa)
Caspase mediated cleavage of vimentin at IDVD (259) (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Caspase-mediated cleavage of plectin-1 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Translocation of active caspase-8 to the mitochondrial membrane (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Caspase activation via extrinsic apoptotic signalling pathway (Sus scrofa)
Caspase activation via Death Receptors in the presence of ligand (Sus scrofa)
Caspase-8 processing within TLR4 complex (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Regulation by c-FLIP (Sus scrofa)
Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Intrinsic Pathway for Apoptosis (Sus scrofa)
Activation, myristolyation of BID and translocation to mitochondria (Sus scrofa)
Caspase-8 activates BID by cleavage (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Regulated Necrosis (Sus scrofa)
RIPK1-mediated regulated necrosis (Sus scrofa)
Regulation of necroptotic cell death (Sus scrofa)
RIPK1 is cleaved by CASP8 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
RIPK3 is cleaved by CASP8 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
RIPK1 is cleaved by CASP8 (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
TRAF1 is cleaved by caspases (Sus scrofa)
active caspase-8 [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Caspase-8 dimer [cytosol]
(Sus scrofa)
Participates
as an input of
Caspase-8 binds MALT (Sus scrofa)
Translocation of active caspase-8 to the mitochondrial membrane (Sus scrofa)
as a component of
MALT1:active caspase-8 [cytosol] (Sus scrofa)
as an output of
Caspase-8 processing within TLR4 complex (Sus scrofa)
This entity regulates
Negatively
N4BP1 binds IKBKG
(Sus scrofa)
Inferred From
active caspase-8 [cytosol]
(Homo sapiens)
active caspase-8 [cytosol]
(Homo sapiens)
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