Reactome | CFLAR [cytosol]

CFLAR [cytosol]

Stable Identifier

R-SSC-3465408

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

CFLAR(1-376), A0A286ZZW1

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Sus scrofa)

- Apoptosis (Sus scrofa)
  - Caspase activation via extrinsic apoptotic signalling pathway (Sus scrofa)
    - Caspase activation via Death Receptors in the presence of ligand (Sus scrofa)
      - Regulation by c-FLIP (Sus scrofa)
        
        Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Sus scrofa)
        
        CFLAR [cytosol] (Sus scrofa)
- Regulated Necrosis (Sus scrofa)
  - RIPK1-mediated regulated necrosis (Sus scrofa)
    - Regulation of necroptotic cell death (Sus scrofa)
      - CASP8 activity is inhibited (Sus scrofa)
        
        FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)
        
        CFLAR [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZZW1

Gene Names

CFLAR

Reference Genes

BioGPS Gene:414381 CFLAR

ENSEMBL:ENSSSCG00000016101

Monarch:414381 CFLAR

NCBI Gene:414381 CFLAR

Reference Transcript

Other Identifiers

414381

GO:0002020

GO:0003674

GO:0004197

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0006915

GO:0007165

GO:0008047

GO:0008150

GO:0008219

GO:0008233

GO:0008234

GO:0019899

GO:0030234

GO:0031264

GO:0032991

GO:0042981

GO:0043123

GO:0060544

GO:0097342

GO:1902042

GO:2001237

Ssc.9544.1.S1_at

Ssc.9544.2.S1_a_at

Participates

as a component of

as an input of

FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)

Other forms of this molecule

CFLAR [cytosol]

Inferred From

CFLAR(1-376) [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005652498.1, XP_013851842.1, XP_005652499.1, XP_013851787.1, XP_013851819.1, XP_005652501.1, XP_005652500.1

OpenTargets

ENSG00000003402

Ensembl

ENSSSCG00000016101, ENSSSCT00000053079, ENSSSCP00000037053

VGNC

95894