Reactome | AGTR1 [plasma membrane]

AGTR1 [plasma membrane]

Stable Identifier

R-SSC-374247

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

P30555

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - ARRB bind GPCRs (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        ARRB-binding GPCRs [plasma membrane] (Sus scrofa)
        
        AGTR1 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:P30555

Reference Genes

BioGPS Gene:100519976

ENSEMBL:ENSSSCG00000011695.5

ENSEMBL:ENSSSCG00005021724.1

ENSEMBL:ENSSSCG00015053993.1

ENSEMBL:ENSSSCG00025028692.1

ENSEMBL:ENSSSCG00030044196.1

ENSEMBL:ENSSSCG00035007839.1

ENSEMBL:ENSSSCG00040070419.1

ENSEMBL:ENSSSCG00045032665.1

ENSEMBL:ENSSSCG00050056820.1

ENSEMBL:ENSSSCG00055021872.1

ENSEMBL:ENSSSCG00060063200.1

ENSEMBL:ENSSSCG00065071012.1

ENSEMBL:ENSSSCG00070006005.1

KEGG Gene (Sus scrofa):100519976

Monarch:100519976

NCBI Gene:100519976

Reference Transcript

RefSeq:XM_003132469.3

Other Identifiers

100519976

GO:0001596

GO:0001822

GO:0002034

GO:0003013

GO:0003014

GO:0004930

GO:0004945

GO:0005886

GO:0007186

GO:0007200

GO:0007204

GO:0007266

GO:0010744

GO:0016020

GO:0019229

GO:0019722

GO:0023052

GO:0030154

GO:0031711

GO:0038166

GO:0046718

GO:0046982

GO:0048856

GO:0048870

GO:0050886

GO:0051247

GO:0060089

GO:0060326

GO:0086097

GO:1903589

Ssc.19059.1.A1_at

Participates

as a candidate of

ARRB-binding GPCRs [plasma membrane] (Sus scrofa)

as an input of

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Sus scrofa)

as a component of

Other forms of this molecule

AGTR1 [clathrin-coated endocytic vesicle membrane]

Inferred From

AGTR1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_003132517.1

ZINC - Substances

AGTR1_PIG

ZINC target

P30555

Ensembl

ENSSSCG00000011695, ENSSSCT00000034453, ENSSSCP00000030853

PRO

P30555

ZINC - Predictions - Purchasable

AGTR1_PIG

VGNC

85191

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