Reactome | Ligand:GPCR complexes that activate Gi [plasma membrane]

Ligand:GPCR complexes that activate Gi [plasma membrane]

Stable Identifier

R-SSC-380091

Type

Set [DefinedSet]

Species

Sus scrofa

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Participants

members

AGTR2:AGT(34-41) [plasma membrane] (Sus scrofa)
APLNR:Apelin peptides [plasma membrane] (Sus scrofa)
C5AR1:C5a [plasma membrane] (Sus scrofa)
GPER1:ESTG [plasma membrane] (Sus scrofa)
Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Sus scrofa)
Nociceptin receptor:Nociceptin [plasma membrane] (Sus scrofa)
Opioid receptor:opioid ligand [plasma membrane] (Sus scrofa)
CCR1,2,8:CCL16 [plasma membrane] (Sus scrofa)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
CCR10:CCL27,28 [plasma membrane] (Sus scrofa)
CCR6:CCL20 [plasma membrane] (Sus scrofa)
CCR7:CCL19,21 [plasma membrane] (Sus scrofa)
CCR9:CCL25 [plasma membrane] (Sus scrofa)
CXCR1:CXCR1 ligands [plasma membrane] (Sus scrofa)
CXCR2:CXCR2 ligands [plasma membrane] (Sus scrofa)
CXCR3:CXCR3 ligands [plasma membrane] (Sus scrofa)
CXCR4,7:CXCL12 [plasma membrane] (Sus scrofa)
CXCR5:CXCL13 [plasma membrane] (Sus scrofa)
CXCR6:CXCL16 [plasma membrane] (Sus scrofa)
Somatostatin receptor:somatostatin [plasma membrane] (Sus scrofa)
HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Sus scrofa)
DRD3,4:DA [plasma membrane] (Sus scrofa)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Sus scrofa)
CHRM2,CHRM4:AcCho [plasma membrane] (Sus scrofa)
P2RY4:UTP [plasma membrane] (Sus scrofa)
P2RY12:ADP [plasma membrane] (Sus scrofa)
P2RY13:ADP [plasma membrane] (Sus scrofa)
P2RY14:UDP-Glc [plasma membrane] (Sus scrofa)
ADORA1,3:Ade-Rib [plasma membrane] (Sus scrofa)
CNRs:Cannabinoids [plasma membrane] (Sus scrofa)
CASR:Ca2+ [plasma membrane] (Sus scrofa)
GALR1-3:GAL [plasma membrane] (Sus scrofa)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Sus scrofa)
LPAR1,2,3,5:LPA [plasma membrane] (Sus scrofa)
Melatonin receptors:melatonin [plasma membrane] (Sus scrofa)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Sus scrofa)
PTGER3:PGE2 [plasma membrane] (Sus scrofa)
S1PR2-5:S1P [plasma membrane] (Sus scrofa)
RXFP3:Relaxin-3 [plasma membrane] (Sus scrofa)
RXFP4:RXFP4 ligands [plasma membrane] (Sus scrofa)
GPR18:NAGLY [plasma membrane] (Sus scrofa)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Sus scrofa)
NMUR1,NMUR2:NMU [plasma membrane] (Sus scrofa)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Sus scrofa)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Sus scrofa)
SUCNR1:SUCCA [plasma membrane] (Sus scrofa)
HCAR1:LACT [plasma membrane] (Sus scrofa)
HCAR2:HCAR2 ligands [plasma membrane] (Sus scrofa)
HCAR3:HCAR3 ligands [plasma membrane] (Sus scrofa)
CCR8:CCL1 [plasma membrane] (Sus scrofa)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Sus scrofa)
GPR183:7alpha,25-dihydroxycholesterol [plasma membrane] (Sus scrofa)
GPR37:PSAP fragments [plasma membrane] (Sus scrofa)
GPR37L1:Prosaposin fragments [plasma membrane] (Sus scrofa)
GPR31:12(S)-HETE [plasma membrane] (Sus scrofa)
GABBR1:GABBR2:GABA [plasma membrane] (Sus scrofa)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Sus scrofa)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Sus scrofa)

Participates

as a component of

Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)

as an input of

Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)

as an output of

The Ligand:GPCR:Gi complex dissociates (Sus scrofa)

Inferred From

Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)