Reactome | FANCE [nucleoplasm]

FANCE [nucleoplasm]

Stable Identifier

R-SSC-419543

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

FANCE, A0A5K1V9E1

Locations in the PathwayBrowser

Expand all

DNA Repair (Sus scrofa)

- Fanconi Anemia Pathway (Sus scrofa)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - FANCE [nucleoplasm] (Sus scrofa)
  - FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - Monoubiquitination of FANCD2:FANCI (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - POLN binds ICL-DNA (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
  - Translesion synthesis across unhooked ICL by POLN (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCE [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex [nucleoplasm] (Sus scrofa)
      - FANCE [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5K1V9E1

Gene Names

FANCE

Reference Genes

ENSEMBL:ENSSSCG00000001546.5

Other Identifiers

GO:0000785

GO:0005634

GO:0005654

GO:0005694

GO:0005813

GO:0005815

GO:0005856

GO:0006281

GO:0006513

GO:0036211

GO:0036297

GO:0043226

GO:0043240

Ssc.21240.1.S1_at

Participates

as a component of

as an input of

FA core complex assembles at DNA interstrand crosslinks (ICLs) (Sus scrofa)

Other forms of this molecule

FANCE [cytosol]

Inferred From

FANCE [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000112039

Ensembl

ENSSSCT00000026873, ENSSSCP00000020351, ENSSSCG00000001546

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