Reactome | H3C14 [nucleoplasm]

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - Senescence-Associated Secretory Phenotype (SASP) (Sus scrofa)
      - EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)
        
        IL6 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
      - EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)
        
        IL8 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)

Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - HDMs demethylate histones (Sus scrofa)
    - KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Sus scrofa)
      - Me2K10-histone H3 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
    - KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)
      - Me2K10-histone H3 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
    - KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)
      - Me2K10-histone H3 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
  - PKMTs methylate histone lysines (Sus scrofa)
    - EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)
      - Me2K10-histone H3 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
    - SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)
      - Me2K10-histone H3 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- Epigenetic regulation of gene expression (Sus scrofa)
  - Negative epigenetic regulation of rRNA expression (Sus scrofa)
    - NoRC negatively regulates rRNA expression (Sus scrofa)
      - MBD2 binds methylcytosine in chromatin (Sus scrofa)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
    - SIRT1 negatively regulates rRNA expression (Sus scrofa)
      - Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
      - eNoSC deacetylates histone H3 (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
      - eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Promoter Escape (Sus scrofa)
      - Elongation of pre-rRNA transcript (Sus scrofa)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
    - RNA Polymerase I Promoter Opening (Sus scrofa)
      - UBF-1 Binds rDNA Promoter (Sus scrofa)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)

Hemostasis (Sus scrofa)

- Factors involved in megakaryocyte development and platelet production (Sus scrofa)
  - JMJD1C demethylates H3K9 mono- and di-methylation (Sus scrofa)
    - Histone H3 mono or di-methylated at K9 [nucleoplasm] (Sus scrofa)
      - Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Nuclear Receptors (Sus scrofa)
  - ESR-mediated signaling (Sus scrofa)
    - Estrogen-dependent gene expression (Sus scrofa)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Sus scrofa)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
      - KDM1A is recruited to MYC and BCL2 genes (Sus scrofa)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
      - Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)
        
        MYC gene, BCL2 gene: H3K9me2 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        H3C14 [nucleoplasm] (Sus scrofa)