Reactome | SH2D2A [cytosol]

SH2D2A [cytosol]

Stable Identifier

R-SSC-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

SH2D2A, A0A286ZQC3

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - AXL autophosphorylates on Y779 and Y821 (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
      - AXL binds SRC-1 (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
      - Phosphorylation of SRC-1 (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
      - p-6Y-VEGFR2 binds SH2D2A (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
      - p-AXL binds PI3K (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)
        
        SH2D2A [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZQC3

Gene Names

SH2D2A

Reference Genes

ENSEMBL:ENSSSCG00000006466.4

Other Identifiers

100153265

GO:0005737

Participates

as an input of

p-6Y-VEGFR2 binds SH2D2A (Sus scrofa)

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Sus scrofa)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000027869

Ensembl

ENSSSCP00000033800, ENSSSCG00000006466, ENSSSCT00000043759

VGNC

92808