Reactome | RAC1:GTP [plasma membrane]

Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - EPH-Ephrin signaling (Sus scrofa)
      - EPH-ephrin mediated repulsion of cells (Sus scrofa)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - EPHB-mediated forward signaling (Sus scrofa)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
    - L1CAM interactions (Sus scrofa)
      - Signal transduction by L1 (Sus scrofa)
        
        Activation of Rac1 by VAV2 (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Interaction of PAK1 with Rac1-GTP (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        pPAK1:Rac1-GTP [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
    - Semaphorin interactions (Sus scrofa)
      - Sema3A PAK dependent Axon repulsion (Sus scrofa)
        
        Activation of PAK by Rac1 (Sus scrofa)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Sus scrofa)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Autophosphorylation of PAK (Sus scrofa)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Sus scrofa)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Sus scrofa)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Phosphorylation of LIMK-1 by PAK (Sus scrofa)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Sus scrofa)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - Sema4D in semaphorin signaling (Sus scrofa)
        
        Sema4D mediated inhibition of cell attachment and migration (Sus scrofa)
        
        Active Rac1 interacts with Plexin-B1:Sema4D (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Costimulation by the CD28 family (Sus scrofa)
    - CD28 co-stimulation (Sus scrofa)
      - CD28 dependent Vav1 pathway (Sus scrofa)
        
        Activation of PAKs by RAC1 and CDC42 (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Activation of Rac1 by pVav1 (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - DAP12 interactions (Sus scrofa)
    - DAP12 signaling (Sus scrofa)
      - Activation of RAC1 by VAV2/3 (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated MAPK activation (Sus scrofa)
      - Activation of RAC1 by VAV (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - Autophosphorylation of PAK (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - ABL phosphorylates WAVEs (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - Activation of RAC1 by VAV (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - Autophosphorylation of PAK1 (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - Detachment of WASP/WAVE (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RAC1 and CDC42 activate PAK1 (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - p-ERK phosphorylates WAVEs and ABI (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
    - RAC1,RAC2,RHOG activate PI3K (Sus scrofa)
      - RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK6/MAPK4 signaling (Sus scrofa)
    - Activation of PAKs by RAC1 and CDC42 (Sus scrofa)
      - CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
    - Autophosphorylation of PAK1,2,3 (Sus scrofa)
      - CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
- Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by PTK6 (Sus scrofa)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Sus scrofa)
      - Activation of RAC1 by the PXN:CRK complex (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by MET (Sus scrofa)
    - MET promotes cell motility (Sus scrofa)
      - MET activates RAP1 and RAC1 (Sus scrofa)
        
        DOCK7 activates RAC1 (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
  - Signaling by NTRKs (Sus scrofa)
    - Signaling by NTRK2 (TRKB) (Sus scrofa)
      - Activated NTRK2 signals through FYN (Sus scrofa)
        
        NTRK2 activates RAC1 (Sus scrofa)
        
        DOCK3 activates RAC1 (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
  - Signaling by SCF-KIT (Sus scrofa)
    - Activation of RAC1 (Sus scrofa)
      - RAC1:GTP [plasma membrane] (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)
        
        NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
        
        NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - VEGFR2 mediated vascular permeability (Sus scrofa)
        
        PAK1-3 autophosphorylates (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        PAK1-3 dimer disassociates (Sus scrofa)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1 binds PAK1-3 (Sus scrofa)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
  - Signaling by Rho GTPases (Sus scrofa)
    - RHO GTPase Effectors (Sus scrofa)
      - RHO GTPases Activate Formins (Sus scrofa)
        
        SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)
        
        RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Sus scrofa)
        
        RAC1:GTP:FMNL1 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Sus scrofa)
        
        RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Sus scrofa)
        
        RAC1:GTP:FMNL1 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Sus scrofa)
        
        RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Sus scrofa)
        
        RAC1:GTP:FMNL1 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RHO GTPases Activate NADPH Oxidases (Sus scrofa)
        
        NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)
        
        NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
        
        NOX2 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
        
        NOX1 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
        
        NOX3 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP binds NOX1 complex (Sus scrofa)
        
        NOX1 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP binds NOX3 complex (Sus scrofa)
        
        NOX3 complex:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RHO GTPases Activate WASPs and WAVEs (Sus scrofa)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        ABL phosphorylates WAVEs (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        Detachment of WASP/WAVE (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-ERK phosphorylates WAVEs and ABI (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RHO GTPases activate CIT (Sus scrofa)
        
        CIT-3 binds DLG4 (Sus scrofa)
        
        RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Sus scrofa)
        
        RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Sus scrofa)
        
        RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Sus scrofa)
        
        RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RHO GTPases activate IQGAPs (Sus scrofa)
        
        GTP-bound RAC1 and CDC42 bind IQGAPs (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        IQGAP1 binds CLIP1 and microtubules (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAP1:CLIP1:microtubule [plasma membrane] (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        IQGAPs bind CALM1 (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        IQGAPs bind F-actin, which is inhibited by calmodulin (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Sus scrofa)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
      - RHO GTPases activate PAKs (Sus scrofa)
        
        Autophosphorylation of PAK1,2,3 (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1 and CDC42 activate PAK1 (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1 and CDC42 activate PAK2 (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Sus scrofa)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
    - RHO GTPase cycle (Sus scrofa)
      - RAC1 GTPase cycle (Sus scrofa)
        
        RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1 GEFs activate RAC1 (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1 binds effectors at the plasma membrane (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)
        
        RAC1 translocates to the endoplasmic reticulum membrane (Sus scrofa)
        
        RAC1:GTP [plasma membrane] (Sus scrofa)