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NUMB [plasma membrane]
Stable Identifier
R-SSC-443595
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
plasma membrane
Synonyms
NUMB, A0A287A1C6
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Signaling by Hedgehog (Sus scrofa)
Hedgehog 'off' state (Sus scrofa)
Degradation of GLI1 by the proteasome (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB binds ITCH (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
Hedgehog 'on' state (Sus scrofa)
NUMB binds ITCH (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH binds GLI1 (Sus scrofa)
GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)
GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
ub-GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
ub-GLI is degraded by the proteasome (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
ub-GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB [plasma membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287A1C6
Gene Names
NUMB
Reference Genes
ENSEMBL:ENSSSCG00000022178.4
Other Identifiers
100522019
GO:0005768
GO:0005769
GO:0005886
GO:0005905
GO:0007399
GO:0007405
GO:0007409
GO:0008013
GO:0016192
GO:0016323
GO:0021670
GO:0021849
GO:0030136
GO:0030154
GO:0030335
GO:0030900
GO:0031410
GO:0034330
GO:0034332
GO:0043226
GO:0045177
GO:0045294
GO:0045296
GO:0048856
GO:0048870
GO:0050769
GO:0072659
GO:0098978
GO:0099149
GO:1903077
Ssc.20190.1.S1_at
Participates
as an input of
NUMB binds ITCH (Sus scrofa)
as a component of
NUMB:ITCH [cytosol] (Sus scrofa)
Inferred From
NUMB [plasma membrane]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000133961
Ensembl
ENSSSCP00000037556
,
ENSSSCG00000022178
,
ENSSSCT00000042673
VGNC
90970
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