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APEX1 [nucleoplasm]
Stable Identifier
R-SSC-50119
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
nucleoplasm
Synonyms
A0A287BTC2
Locations in the PathwayBrowser
Expand all
DNA Repair (Sus scrofa)
Base Excision Repair (Sus scrofa)
Resolution of Abasic Sites (AP sites) (Sus scrofa)
APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Displacement of DNA glycosylase by APEX1 (Sus scrofa)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Displacement of UNG glycosylase by APEX1 at the AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
Oxidative damage to the AP site (Sus scrofa)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
PCNA-Dependent Long Patch Base Excision Repair (Sus scrofa)
LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB-Dependent Long Patch Base Excision Repair (Sus scrofa)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Recruitment of POLB to oxidatively damaged AP site (Sus scrofa)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Resolution of AP sites via the single-nucleotide replacement pathway (Sus scrofa)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Sus scrofa)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
Recruitment of POLB to the AP site (Sus scrofa)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1 [nucleoplasm] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287BTC2
Reference Genes
ENSEMBL:ENSSSCG00000040060.2
UCSC:A0A287BTC2
Participates
as an output of
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)
as a component of
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Sus scrofa)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Sus scrofa)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
APEX1:AP-dsDNA [nucleoplasm] (Sus scrofa)
as an input of
Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of UNG glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Sus scrofa)
Inferred From
APEX1 [nucleoplasm]
(Homo sapiens)
Cross References
VGNC
103896
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