Reactome | phospho-PXN [cytosol]

phospho-PXN [cytosol]

Stable Identifier

R-SSC-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-Y31,Y118-PXN, A0A5G2RG25

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by PTK6 (Sus scrofa)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Sus scrofa)
      - Activation of RAC1 by the PXN:CRK complex (Sus scrofa)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
      - PTK6 phosphorylates PXN (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
      - Phosphorylated PXN recruits the CRK complex (Sus scrofa)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - CRK binds BCAR1 and or PXN (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
      - DOCK180:ELMO binds CRK (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        phospho-PXN [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2RG25

Gene Names

PXN

Reference Genes

ENSEMBL:ENSSSCG00000040546.3

Other Identifiers

110256718

GO:0005829

GO:0005856

GO:0005925

GO:0005938

GO:0007155

GO:0043226

GO:0046872

Ssc.4085.1.S1_at

Participates

as a component of

as an input of

Phosphorylated PXN recruits the CRK complex (Sus scrofa)

as an output of

PTK6 phosphorylates PXN (Sus scrofa)

Other forms of this molecule

phospho-PXN [plasma membrane]

PXN [plasma membrane]

PXN [cytosol]

Inferred From

p-Y31,Y118-PXN [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31 (in Homo sapiens)

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118 (in Homo sapiens)

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000089159

Ensembl

ENSSSCG00000040546, ENSSSCP00000070084, ENSSSCT00000089030