Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-MLKL [cytosol]
Stable Identifier
R-SSC-5218903
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
p-T357,S358-MLKL, A0A287AG10
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Sus scrofa)
Regulated Necrosis (Sus scrofa)
RIPK1-mediated regulated necrosis (Sus scrofa)
MLKL binds PIPs (Sus scrofa)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
RIPK3 phosphorylates MLKL (Sus scrofa)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
Regulation of necroptotic cell death (Sus scrofa)
ITCH polyubiquitinates MLKL at K50 (Sus scrofa)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Sus scrofa)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
MLKL binds FLOT1, FLOT2 (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
MLKL binds IP4, IP5 and IP6 (Sus scrofa)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Sus scrofa)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
MLKL binds ITCH (Sus scrofa)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Sus scrofa)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
MLKL binds PDCD6IP and SDCBP (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
Transport of small molecules (Sus scrofa)
Ion channel transport (Sus scrofa)
Stimuli-sensing channels (Sus scrofa)
TRP channels (Sus scrofa)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
TRPV1 transports Ca2+ from extracellular region to cytosol (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
TRPs transport extracellular Ca2+ to cytosol (Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
phospho-MLKL [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287AG10
Gene Names
MLKL
Reference Genes
BioGPS Gene:100736836 MLKL
ENSEMBL:ENSSSCG00000002716.5
KEGG Gene (Sus scrofa):100736836 MLKL
Monarch:100736836 MLKL
NCBI Gene:100736836 MLKL
Reference Transcript
RefSeq:XM_003481791.3 MLKL
Other Identifiers
100736836
GO:0003824
GO:0004672
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007166
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0023052
GO:0030054
GO:0036211
GO:0043226
GO:0044877
GO:0051607
GO:0065003
GO:0070207
GO:0070266
GO:0097527
GO:0097528
GO:0098542
GO:0140096
Participates
as a repeated unit of
p-T357,S358-MLKL oligomer [cytosol] (Sus scrofa)
as a component of
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Sus scrofa)
Other forms of this molecule
phospho-MLKL [cytosol]
MLKL [cytosol]
Inferred From
p-T357,S358-MLKL [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 358 (in Homo sapiens)
Coordinate
358
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 357 (in Homo sapiens)
Coordinate
357
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_003481839.2
OpenTargets
ENSG00000168404
Ensembl
ENSSSCP00000042792
,
ENSSSCG00000002716
,
ENSSSCT00000054953
VGNC
90254
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text