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BIRC2,3,4 [cytosol]
Stable Identifier
R-SSC-5357900
Type
Set [CandidateSet]
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Sus scrofa)
Regulated Necrosis (Sus scrofa)
RIPK1-mediated regulated necrosis (Sus scrofa)
Regulation of necroptotic cell death (Sus scrofa)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Sus scrofa)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
K63polyUb-RIPK1 is deubiquitinated (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
OPTN recruits CYLD to the TNFR1 complex (Sus scrofa)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Sus scrofa)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Sus scrofa)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNFR1-induced NF-kappa-B signaling pathway (Sus scrofa)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
TNFR1-induced proapoptotic signaling (Sus scrofa)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
BIRC2,3,4 [cytosol] (Sus scrofa)
Participants
members
BIRC2 [cytosol]
(Sus scrofa)
BIRC3 [cytosol]
(Sus scrofa)
candidates
XIAP [cytosol]
(Sus scrofa)
Participates
as a component of
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
as an output of
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
as an input of
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Sus scrofa)
Inferred From
BIRC2,3,4 [cytosol]
(Homo sapiens)
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