Reactome | PARP2 [nucleoplasm]

PARP2 [nucleoplasm]

Stable Identifier

R-SSC-5651715

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

PAR-PARP2, A0A287AL90

Locations in the PathwayBrowser

Expand all

DNA Repair (Sus scrofa)

- Base Excision Repair (Sus scrofa)
  - Resolution of Abasic Sites (AP sites) (Sus scrofa)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
      - POLB-Dependent Long Patch Base Excision Repair (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        PARG dePARylates PARP1,PARP2 (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
- DNA Double-Strand Break Repair (Sus scrofa)
  - Homology Directed Repair (Sus scrofa)
    - HDR through MMEJ (alt-NHEJ) (Sus scrofa)
      - PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
- Nucleotide Excision Repair (Sus scrofa)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
    - DNA Damage Recognition in GG-NER (Sus scrofa)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
    - Dual Incision in GG-NER (Sus scrofa)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Sus scrofa)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
    - Formation of Incision Complex in GG-NER (Sus scrofa)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Sus scrofa)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Sus scrofa)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - CHD1L is recruited to GG-NER site (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - Formation of the pre-incision complex in GG-NER (Sus scrofa)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - Recruitment of XPA and release of CAK (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - SUMOylation of XPC (Sus scrofa)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
      - TFIIH binds GG-NER site to form a verification complex (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
        
        PARP2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AL90

Gene Names

PARP2

Reference Genes

ENSEMBL:ENSSSCG00000002143.5

Other Identifiers

100518917

GO:0003677

GO:0003682

GO:0003684

GO:0003824

GO:0003950

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006281

GO:0006284

GO:0006325

GO:0006974

GO:0012501

GO:0016740

GO:0016757

GO:0016779

GO:0022414

GO:0023052

GO:0030592

GO:0031491

GO:0043226

GO:0046697

GO:0048856

GO:0072572

GO:0090734

GO:0097191

GO:0140096

GO:0140294

GO:0140805

GO:0140806

GO:0140807

GO:0140861

GO:0160004

GO:1990404

Ssc.17303.1.S1_at

Participates

as a candidate of

PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)

Other forms of this molecule

PARP2 [nucleoplasm]

Inferred From

PAR-PARP2 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

L-glutamyl-5-poly(ADP-ribose) at unknown position

PsiMod Name

L-glutamyl-5-poly(ADP-ribose)

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose).

Cross References

OpenTargets

ENSG00000129484

Ensembl

ENSSSCG00000002143, ENSSSCP00000044669, ENSSSCT00000037795

Cite Us!