Reactome | LAMTOR1 [lysosomal membrane]

LAMTOR1 [lysosomal membrane]

Stable Identifier

R-SSC-5653582

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

lysosomal membrane

Synonyms

LAMTOR1, A0A5G2RET7

Locations in the PathwayBrowser

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Autophagy (Sus scrofa)

- Macroautophagy (Sus scrofa)
  - Active MTORC1 binds the ULK1 complex (Sus scrofa)
    - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Active MTORC1 phosphorylates ULK1 (Sus scrofa)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - MTORC1 dissociates from ULK complex (Sus scrofa)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Sus scrofa)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Sus scrofa)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Sus scrofa)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Rheb in the MTORC1 complex hydrolyses GTP (Sus scrofa)
    - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Sus scrofa)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular response to starvation (Sus scrofa)
    - Amino acids regulate mTORC1 (Sus scrofa)
      - RRAGA,B exchanges GDP for GTP (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - RRAGA,B hydrolyzes GTP (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - RRAGC,D exchanges GTP for GDP (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - RRAGC,D hydrolyzes GTP (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - mTORC1 binds RHEB:GTP (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        v-ATPase:Ragulator [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - TP53 Regulates Metabolic Genes (Sus scrofa)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)
        
        Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- MTOR signalling (Sus scrofa)
  - AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)
    - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Sus scrofa)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Formation of Ragulator complex (Sus scrofa)
    - LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - Ragulator [lysosomal membrane] (Sus scrofa)
      - LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Formation of active mTORC1 complex (Sus scrofa)
    - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Sus scrofa)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Sus scrofa)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
        
        Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Ragulator binds Rag dimers (Sus scrofa)
    - Ragulator [lysosomal membrane] (Sus scrofa)
      - LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
      - Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - SLC38A9 binds Ragulator:Rag dimers (Sus scrofa)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
      - Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Sus scrofa)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - mTORC1 phosphorylates AKT1S1 (Sus scrofa)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Sus scrofa)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
        
        Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Sus scrofa)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
        
        Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
  - mTORC1-mediated signalling (Sus scrofa)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Sus scrofa)
        
        Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Sus scrofa)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
        
        Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Sus scrofa)
      - Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Sus scrofa)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Sus scrofa)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
        
        Active mTORC1 complex [lysosomal membrane] (Sus scrofa)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Sus scrofa)
        
        Ragulator [lysosomal membrane] (Sus scrofa)
        
        LAMTOR1 [lysosomal membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2RET7

Gene Names

LAMTOR1

Reference Genes

ENSEMBL:ENSSSCG00000014804

Other Identifiers

100520503

GO:0001558

GO:0001919

GO:0003674

GO:0005085

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0006464

GO:0006629

GO:0006810

GO:0007032

GO:0007040

GO:0007165

GO:0008150

GO:0010872

GO:0010874

GO:0016192

GO:0016197

GO:0019899

GO:0031410

GO:0031902

GO:0032008

GO:0032418

GO:0032991

GO:0034613

GO:0040007

GO:0042592

GO:0042632

GO:0043226

GO:0043410

GO:0045121

GO:0051020

GO:0060090

GO:0060620

GO:0071230

GO:0071986

Ssc.3302.1.S1_at

Participates

as an input of

Formation of Ragulator complex (Sus scrofa)

as a component of

Ragulator [lysosomal membrane] (Sus scrofa)

Other forms of this molecule

LAMTOR1 [ficolin-1-rich granule membrane]

LAMTOR1 [azurophil granule membrane]

LAMTOR1 [plasma membrane]

LAMTOR1 [specific granule membrane]

Inferred From

LAMTOR1 [lysosomal membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000149357

Ensembl

ENSSSCT00000081655, ENSSSCG00000014804, ENSSSCP00000073191

VGNC

89629

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