Reactome | IRS2 [cytosol]

IRS2 [cytosol]

Stable Identifier

R-SSC-57528

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

IRS2, A0A287B726

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by Erythropoietin (Sus scrofa)
  - EPOR binds EPOR agonists (Sus scrofa)
    - EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
      - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
    - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
      - IRS2 [cytosol] (Sus scrofa)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Sus scrofa)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - PI3K bound to EPOR [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
    - JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
  - Erythropoietin activates RAS (Sus scrofa)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by Insulin receptor (Sus scrofa)
    - Insulin receptor signalling cascade (Sus scrofa)
      - IRS activation (Sus scrofa)
        
        Binding of IRS to insulin receptor (Sus scrofa)
        
        IRS1,2 [cytosol] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
        
        IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
        
        IRS1,2 [cytosol] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
        
        Phosphorylation of IRS (Sus scrofa)
        
        IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Sus scrofa)
        
        IRS1,2 [cytosol] (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
    - IGF1R signaling cascade (Sus scrofa)
      - IRS-related events triggered by IGF1R (Sus scrofa)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)
        
        IRS2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B726

Gene Names

IRS2

Reference Genes

ENSEMBL:ENSSSCG00000034763.2

UCSC:A0A287B726 IRS2

Other Identifiers

110255858

GO:0002053

GO:0002376

GO:0002903

GO:0005068

GO:0005158

GO:0005829

GO:0005886

GO:0005975

GO:0006091

GO:0006629

GO:0007420

GO:0008283

GO:0008284

GO:0008286

GO:0009749

GO:0010631

GO:0010634

GO:0010748

GO:0010907

GO:0012501

GO:0016477

GO:0019901

GO:0023052

GO:0030674

GO:0030879

GO:0030890

GO:0032000

GO:0032024

GO:0032869

GO:0043548

GO:0044342

GO:0045725

GO:0046326

GO:0048856

GO:0048870

GO:0051897

GO:0055085

GO:0060090

GO:0141038

GO:1904692

Ssc.24696.1.S1_at

Ssc.24696.2.S1_at

Participates

as a member of

as a component of

as an input of

IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)

Other forms of this molecule

IRS2 [plasma membrane]

phospho-IRS2 [cytosol]

phospho-IRS2 [plasma membrane]

Inferred From

IRS2 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCP00000052323, ENSSSCT00000043241, ENSSSCG00000034763

VGNC

89214

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