Reactome | RPAP2 [nucleoplasm]

RPAP2 [nucleoplasm]

Stable Identifier

R-SSC-6810227

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

RPAP2, A0A5G2R4N4

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA polymerase II transcribes snRNA genes (Sus scrofa)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
    - Integrator complex processes the 3' end of snRNA (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)
      - RPAP2 [nucleoplasm] (Sus scrofa)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Sus scrofa)
        
        RPAP2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2R4N4

Gene Names

RPAP2

Reference Genes

ENSEMBL:ENSSSCG00000006903.5

Other Identifiers

100517893

GO:0003824

GO:0004721

GO:0004722

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0008420

GO:0009301

GO:0016073

GO:0016787

GO:0017018

GO:0023052

GO:0036499

GO:0043175

GO:0043226

GO:0046872

GO:0097550

GO:0140096

Ssc.11805.1.A1_a_at

Participates

as a component of

as an input of

RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)

Inferred From

RPAP2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000122484

Ensembl

ENSSSCG00000006903, ENSSSCT00000082015, ENSSSCP00000072173

VGNC

92418