Reactome | RPRD2 [nucleoplasm]

RPRD2 [nucleoplasm]

Stable Identifier

R-SSC-6814906

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

RPRD2, A0A287B756

Locations in the PathwayBrowser

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Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA polymerase II transcribes snRNA genes (Sus scrofa)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
    - Integrator complex processes the 3' end of snRNA (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Sus scrofa)
        
        RPRD2 [nucleoplasm] (Sus scrofa)
      - RPRD2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B756

Gene Names

RPRD2

Reference Genes

BioGPS Gene:100620276 RPRD2

ENSEMBL:ENSSSCG00000030291.4

KEGG Gene (Sus scrofa):100620276 RPRD2

Monarch:100620276 RPRD2

NCBI Gene:100620276 RPRD2

Reference Transcript

RefSeq:XM_003355198.3 RPRD2

Other Identifiers

100620276

GO:0097550

GO:0099122

Ssc.17870.1.A1_at

Ssc.22816.1.S1_at

Participates

as a component of

as an input of

RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)

Inferred From

RPRD2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003355246.1

OpenTargets

ENSG00000163125

Ensembl

ENSSSCG00000030291, ENSSSCT00000064242, ENSSSCP00000051945

VGNC

92436