Reactome | DNA polymerase alpha:primase [nucleoplasm]

DNA polymerase alpha:primase [nucleoplasm]

Stable Identifier

R-SSC-68507

Type

Complex

Species

Sus scrofa

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Activation of the pre-replicative complex (Sus scrofa)
    - DNA polymerase alpha:primase binds at the origin (Sus scrofa)
      - DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
      - DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
- Synthesis of DNA (Sus scrofa)
  - DNA replication initiation (Sus scrofa)
    - The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)
      - DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
      - RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
      - RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
    - The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)
      - DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
      - DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
      - RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
  - DNA strand elongation (Sus scrofa)
    - Lagging Strand Synthesis (Sus scrofa)
      - Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Loading of PCNA - Sliding Clamp Formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RFC binding displaces Pol Alpha (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RFC dissociates after sliding clamp formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
      - Processive synthesis on the lagging strand (Sus scrofa)
        
        Formation of Okazaki fragments (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Formation of the Flap Intermediate (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Removal of the Flap Intermediate (Sus scrofa)
        
        RPA binds to the Flap (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Recruitment of Dna2 endonuclease (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Removal of remaining Flap (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
    - Leading Strand Synthesis (Sus scrofa)
      - Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        Loading of PCNA - Sliding Clamp Formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RFC binding displaces Pol Alpha (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RFC dissociates after sliding clamp formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an output of

as an input of

as a component of

Inferred From

DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)

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