Reactome | MCM6 [nucleoplasm]

MCM6 [nucleoplasm]

Stable Identifier

R-SSC-68553

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

MCM6, M3TYJ4

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - Activation of ATR in response to replication stress (Sus scrofa)
      - Activation of claspin (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - Loading of claspin onto DNA during replication origin firing (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Activation of the pre-replicative complex (Sus scrofa)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        Mcm2-7 is phosphorylated by DDK (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        p-MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - Switching of origins to a post-replicative state (Sus scrofa)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        Orc1 removal from chromatin (Sus scrofa)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Activation of the pre-replicative complex (Sus scrofa)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - DNA polymerase alpha:primase binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - DNA polymerase epsilon binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - Mcm2-7 is phosphorylated by DDK (Sus scrofa)
      - MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - p-MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
  - Assembly of the pre-replicative complex (Sus scrofa)
    - Formation of MCM2-7 complex (Sus scrofa)
      - MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - MCM6 [nucleoplasm] (Sus scrofa)
- Synthesis of DNA (Sus scrofa)
  - Switching of origins to a post-replicative state (Sus scrofa)
    - Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
      - MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
    - Orc1 removal from chromatin (Sus scrofa)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM6 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:M3TYJ4

Gene Names

MCM6

Reference Genes

ENSEMBL:ENSSSCG00000035564.3

Other Identifiers

110257107

GO:0000166

GO:0000228

GO:0000278

GO:0000727

GO:0003677

GO:0003678

GO:0003697

GO:0003824

GO:0004386

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006268

GO:0006270

GO:0006281

GO:0006310

GO:0007049

GO:0016787

GO:0031090

GO:0032508

GO:0042555

GO:0042802

GO:0043226

GO:0071162

GO:0140097

GO:0140657

GO:1902969

GO:1990518

Ssc.7202.1.A1_at

Participates

as an input of

MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)

as a component of

MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)

Inferred From

MCM6 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000076003

Ensembl

ENSSSCG00000035564, ENSSSCP00000037726, ENSSSCT00000054881

VGNC

96416

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