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26S proteasome [cytosol]
Stable Identifier
R-SSC-68819
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Sus scrofa)
Cell Cycle Checkpoints (Sus scrofa)
G1/S DNA Damage Checkpoints (Sus scrofa)
p53-Dependent G1/S DNA damage checkpoint (Sus scrofa)
p53-Dependent G1 DNA Damage Response (Sus scrofa)
Stabilization of p53 (Sus scrofa)
Autodegradation of the E3 ubiquitin ligase COP1 (Sus scrofa)
Proteasome mediated degradation of COP1 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
G2/M Checkpoints (Sus scrofa)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
M Phase (Sus scrofa)
Mitotic Metaphase and Anaphase (Sus scrofa)
Mitotic Anaphase (Sus scrofa)
Separation of Sister Chromatids (Sus scrofa)
Degradation of multiubiquitinated Securin (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Mitotic G2-G2/M phases (Sus scrofa)
G2/M Transition (Sus scrofa)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Sus scrofa)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
The role of GTSE1 in G2/M progression after G2 checkpoint (Sus scrofa)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Regulation of mitotic cell cycle (Sus scrofa)
APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Sus scrofa)
Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
APC/C:Cdc20 mediated degradation of Securin (Sus scrofa)
Degradation of multiubiquitinated Securin (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Sus scrofa)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Sus scrofa)
Degradation multiubiquitinated Cyclin A (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
S Phase (Sus scrofa)
Synthesis of DNA (Sus scrofa)
Switching of origins to a post-replicative state (Sus scrofa)
CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Orc1 removal from chromatin (Sus scrofa)
Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Ubiquitin-dependent degradation of Cyclin D (Sus scrofa)
Proteasome mediated degradation of Cyclin D1 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Cell-Cell communication (Sus scrofa)
Cell junction organization (Sus scrofa)
Cell-cell junction organization (Sus scrofa)
Adherens junctions interactions (Sus scrofa)
Regulation of Homotypic Cell-Cell Adhesion (Sus scrofa)
Regulation of Expression and Function of Type I Classical Cadherins (Sus scrofa)
Regulation of CDH1 Expression and Function (Sus scrofa)
Regulation of CDH1 Function (Sus scrofa)
Degradation of CDH1 (Sus scrofa)
Proteasome-dependent degradation of ubiquitinated CDH1 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
KEAP1-NFE2L2 pathway (Sus scrofa)
26S proteasome degrades Ub-NFE2L2 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Circadian clock (Sus scrofa)
Degradation of CRY and PER proteins (Sus scrofa)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
DNA Replication (Sus scrofa)
Synthesis of DNA (Sus scrofa)
Switching of origins to a post-replicative state (Sus scrofa)
CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Orc1 removal from chromatin (Sus scrofa)
Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional regulation by RUNX1 (Sus scrofa)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Sus scrofa)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing-Cross presentation (Sus scrofa)
Cross-presentation of soluble exogenous antigens (endosomes) (Sus scrofa)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
Proteasomal cleavage of substrate (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-inhibition by PD-1 (Sus scrofa)
Regulation of PD-L1(CD274) expression (Sus scrofa)
Regulation of PD-L1(CD274) Post-translational modification (Sus scrofa)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) (Sus scrofa)
Proteasomal degradation of polyUb-p-S195-CD274 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Downstream signaling events of B Cell Receptor (BCR) (Sus scrofa)
Activation of NF-kappaB in B cells (Sus scrofa)
Ubiquitinated IkB is degraded (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
TNFR2 non-canonical NF-kB pathway (Sus scrofa)
26Sproteasome degrades K48polyUb-NIK (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
NIK-->noncanonical NF-kB signaling (Sus scrofa)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Dectin-1 mediated noncanonical NF-kB signaling (Sus scrofa)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Metabolism of polyamines (Sus scrofa)
Regulation of ornithine decarboxylase (ODC) (Sus scrofa)
26S proteosome degrades ODC holoenzyme complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Metabolism of RNA (Sus scrofa)
Regulation of mRNA stability by proteins that bind AU-rich elements (Sus scrofa)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Sus scrofa)
AUF1:mRNA complex is degraded (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Deubiquitination (Sus scrofa)
UCH proteinases (Sus scrofa)
ADRM1 binds 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
ADRM1:26S proteasome:UCHL5 [cytosol] (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Ub-specific processing proteases (Sus scrofa)
ADRM1:26S proteaseome binds USP14 (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
ADRM1:26S proteasome:USP14 [cytosol] (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Neddylation (Sus scrofa)
26S proteasome degrades HIFalpha (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
26S proteasome degrades Ub-NFE2L2 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Translation (Sus scrofa)
Ribosome-associated quality control (Sus scrofa)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide (Sus scrofa)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
PTEN Regulation (Sus scrofa)
Regulation of PTEN stability and activity (Sus scrofa)
Proteasome degrades polyubiquitinated PTEN (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF/MAP kinase cascade (Sus scrofa)
Regulation of RAS by GAPs (Sus scrofa)
NF1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
MAPK6/MAPK4 signaling (Sus scrofa)
MAPK6 is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Signaling by Hedgehog (Sus scrofa)
Hedgehog 'off' state (Sus scrofa)
Degradation of GLI1 by the proteasome (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
GLI3 is processed to GLI3R by the proteasome (Sus scrofa)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Hedgehog 'on' state (Sus scrofa)
ub-GLI is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Hedgehog ligand biogenesis (Sus scrofa)
Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Signaling by WNT (Sus scrofa)
Beta-catenin independent WNT signaling (Sus scrofa)
PCP/CE pathway (Sus scrofa)
Asymmetric localization of PCP proteins (Sus scrofa)
PRICKLE1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
TCF dependent signaling in response to WNT (Sus scrofa)
Degradation of AXIN (Sus scrofa)
Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Degradation of DVL (Sus scrofa)
Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
Transport of small molecules (Sus scrofa)
ABC-family proteins mediated transport (Sus scrofa)
misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
19S regulatory particle [cytosol]
(Sus scrofa)
20S core particle [cytosol]
(Sus scrofa)
Participates
as an input of
ADRM1 binds 26S proteasome (Sus scrofa)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)
as a component of
ADRM1:26S proteasome [cytosol] (Sus scrofa)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Sus scrofa)
as an output of
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)
Inferred From
26S proteasome [cytosol]
(Homo sapiens)
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