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MCM4:MCM6:MCM7 [nucleoplasm]
Stable Identifier
R-SSC-69018
Type
Complex
Species
Sus scrofa
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Sus scrofa)
Cell Cycle Checkpoints (Sus scrofa)
G2/M Checkpoints (Sus scrofa)
Activation of ATR in response to replication stress (Sus scrofa)
Activation of claspin (Sus scrofa)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Loading of claspin onto DNA during replication origin firing (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
Mitotic G1 phase and G1/S transition (Sus scrofa)
G1/S Transition (Sus scrofa)
Activation of the pre-replicative complex (Sus scrofa)
CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
DNA polymerase alpha:primase binds at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
DNA polymerase epsilon binds at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Mcm2-7 is phosphorylated by DDK (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
p-MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
S Phase (Sus scrofa)
Synthesis of DNA (Sus scrofa)
Switching of origins to a post-replicative state (Sus scrofa)
Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Orc1 removal from chromatin (Sus scrofa)
Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
DNA Replication (Sus scrofa)
DNA Replication Pre-Initiation (Sus scrofa)
Activation of the pre-replicative complex (Sus scrofa)
CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
DNA polymerase alpha:primase binds at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
DNA polymerase epsilon binds at the origin (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
active pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Mcm2-7 is phosphorylated by DDK (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
p-MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Assembly of the pre-replicative complex (Sus scrofa)
Formation of MCM2-7 complex (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Synthesis of DNA (Sus scrofa)
Switching of origins to a post-replicative state (Sus scrofa)
Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Orc1 removal from chromatin (Sus scrofa)
Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
pre-replicative complex [nucleoplasm] (Sus scrofa)
MCM2-7 [nucleoplasm] (Sus scrofa)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
MCM4 [nucleoplasm]
(Sus scrofa)
MCM6 [nucleoplasm]
(Sus scrofa)
MCM7 [nucleoplasm]
(Sus scrofa)
Participates
as an output of
Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)
as an input of
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)
as a component of
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
Inferred From
MCM4:MCM6:MCM7 [nucleoplasm]
(Homo sapiens)
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