Reactome | RPS12 [cytosol]

RPS12 [cytosol]

Stable Identifier

R-SSC-72329

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

RPS12, P46405

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS12 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:P46405

Gene Names

RPS12

Reference Genes

BioGPS Gene:397650 RPS12

ENSEMBL:ENSSSCG00000004177.4 RPS12

ENSEMBL:ENSSSCG00005038483.1 RPS12

ENSEMBL:ENSSSCG00015074513.1 RPS12

ENSEMBL:ENSSSCG00025002953.1 RPS12

ENSEMBL:ENSSSCG00030036524.1 RPS12

ENSEMBL:ENSSSCG00035036063.1

ENSEMBL:ENSSSCG00040065172.1 RPS12

ENSEMBL:ENSSSCG00045026421.1 RPS12

ENSEMBL:ENSSSCG00050018386.1 RPS12

ENSEMBL:ENSSSCG00055017713.1 RPS12

ENSEMBL:ENSSSCG00060072109.1 RPS12

ENSEMBL:ENSSSCG00065034515.1 RPS12

ENSEMBL:ENSSSCG00070022487.1 RPS12

KEGG Gene (Sus scrofa):397650 RPS12

Monarch:397650 RPS12

NCBI Gene:397650 RPS12

Reference Transcript

RefSeq:NM_214363.1 RPS12

Other Identifiers

397650

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0043226

GO:0110165

GO:1990904

Ssc.13774.1.S1_at

Participates

as a component of

40S ribosomal complex [cytosol] (Sus scrofa)

Other forms of this molecule

RPS12 [nucleoplasm]

Inferred From

RPS12 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_999528.1

OpenTargets

ENSG00000112306

Ensembl

ENSSSCG00000004177, ENSSSCT00000004616, ENSSSCP00000004510

VGNC

103165

PDB

3J7R

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