Reactome | RPS18 [cytosol]

RPS18 [cytosol]

Stable Identifier

R-SSC-72341

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

RPS18, P62272

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS18 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:P62272

Gene Names

RPS18

Reference Genes

BioGPS Gene:396980 RPS18

ENSEMBL:ENSSSCG00000001502.5 RPS18

ENSEMBL:ENSSSCG00005028347.1 RPS18

ENSEMBL:ENSSSCG00015032681.1 RPS18

ENSEMBL:ENSSSCG00040074457.1 RPS18

ENSEMBL:ENSSSCG00045008633.1

ENSEMBL:ENSSSCG00065047309.1 RPS18

ENSEMBL:ENSSSCG00070008759.1 RPS18

KEGG Gene (Sus scrofa):396980 RPS18

Monarch:396980 RPS18

NCBI Gene:396980 RPS18

Reference Transcript

RefSeq:NM_213940.1 RPS18

Other Identifiers

396980

GO:0003676

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005829

GO:0005840

GO:0006412

GO:0014069

GO:0022626

GO:0022627

GO:0043226

GO:0045202

Ssc.11132.1.S1_a_at

Ssc.11132.1.S1_at

Ssc.13966.1.A1_s_at

Participates

as a component of

40S ribosomal complex [cytosol] (Sus scrofa)

Other forms of this molecule

RPS18 [nucleoplasm]

Inferred From

RPS18 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_999105.1

OpenTargets

ENSG00000231500

Ensembl

ENSSSCP00000001631, ENSSSCT00000084331, ENSSSCT00000001675, ENSSSCP00000067461, ENSSSCG00000001502

PDB

3J7P, 3J7R

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