Reactome | RPL34 [cytosol]

RPL34 [cytosol]

Stable Identifier

R-SSC-72458

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

RPL34, Q29223

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)
- rRNA processing (Sus scrofa)
  - rRNA processing in the nucleus and cytosol (Sus scrofa)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Sus scrofa)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL34 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q29223

Gene Names

RPL34

Reference Genes

BioGPS Gene:100517840 RPL34

ENSEMBL:ENSSSCG00000009146.5 RPL34

ENSEMBL:ENSSSCG00005039984.1 RPL34

ENSEMBL:ENSSSCG00015015743.1 RPL34

ENSEMBL:ENSSSCG00025038271.1 RPL34

ENSEMBL:ENSSSCG00030003785.1

ENSEMBL:ENSSSCG00035021704.1 RPL34

ENSEMBL:ENSSSCG00040074412.1 RPL34

ENSEMBL:ENSSSCG00045025248.1 RPL34

ENSEMBL:ENSSSCG00050013820.1 RPL34

ENSEMBL:ENSSSCG00055007220.1 RPL34

ENSEMBL:ENSSSCG00060076495.1 RPL34

ENSEMBL:ENSSSCG00065007708.1 RPL34

ENSEMBL:ENSSSCG00070019891.1 RPL34

KEGG Gene (Sus scrofa):100517840 RPL34

Monarch:100517840 RPL34

NCBI Gene:100517840 RPL34

Reference Transcript

Other Identifiers

100517840

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0022626

GO:0043226

GO:0045202

Ssc.803.1.A1_at

Participates

as a component of

Inferred From

RPL34 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013834419.1, XP_013834418.1, XP_005667000.1, XP_005666999.1

OpenTargets

ENSG00000109475

Ensembl

ENSSSCP00000009753, ENSSSCG00000009146, ENSSSCT00000010015

VGNC

98957

PDB

3J7O, 3J7P, 3J7Q, 3J7R

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