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NBN [nucleoplasm]
Stable Identifier
R-SSC-75163
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
nucleoplasm
Synonyms
NBN, K7GMW9
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular Senescence (Sus scrofa)
DNA Damage/Telomere Stress Induced Senescence (Sus scrofa)
KAT5 acetylates ATM at DNA DSBs (Sus scrofa)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
KAT5 acetylates ATM at shortened telomeres (Sus scrofa)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN activates ATM (Sus scrofa)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN bound to shortened telomeres activates ATM (Sus scrofa)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN complex binds DNA double strand breaks (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN complex binds shortened telomeres (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN complex bound to DNA ends recruits ATM (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN complex bound to shortened telomeres recruits ATM (Sus scrofa)
Shortened telomere:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
Shortened telomere:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA Repair (Sus scrofa)
DNA Double-Strand Break Repair (Sus scrofa)
DNA Double Strand Break Response (Sus scrofa)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Sus scrofa)
ATM phosphorylates NBN (Sus scrofa)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Sensing of DNA Double Strand Breaks (Sus scrofa)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
KAT5 acetylates ATM at DNA DSBs (Sus scrofa)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
KPNA2 translocates NBN to the nucleus (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN activates ATM (Sus scrofa)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN complex binds DNA double strand breaks (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN complex bound to DNA ends recruits ATM (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Homology Directed Repair (Sus scrofa)
HDR through MMEJ (alt-NHEJ) (Sus scrofa)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
LIG3 ligates remaining SSBs in MMEJ (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN complex binds RBBP8 (Sus scrofa)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
DNA DSBs:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Sus scrofa)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Sus scrofa)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Sus scrofa)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Sus scrofa)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Sus scrofa)
MRN [nucleoplasm] (Sus scrofa)
NBN [nucleoplasm] (Sus scrofa)
External Reference Information
External Reference
UniProt:K7GMW9
Gene Names
NBN
Reference Genes
ENSEMBL:ENSSSCG00000006127.6
UCSC:K7GMW9 NBN
Other Identifiers
100153233
GO:0000077
GO:0000278
GO:0000723
GO:0000781
GO:0001701
GO:0001832
GO:0002376
GO:0003677
GO:0003684
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005730
GO:0005794
GO:0006281
GO:0006302
GO:0006310
GO:0006974
GO:0007049
GO:0007095
GO:0007405
GO:0012501
GO:0016605
GO:0022414
GO:0023052
GO:0030154
GO:0030870
GO:0031860
GO:0031954
GO:0032200
GO:0032206
GO:0032508
GO:0035861
GO:0036211
GO:0042405
GO:0043226
GO:0045190
GO:0048856
GO:0050877
GO:0050885
GO:0051321
GO:0070533
GO:0090656
GO:0090737
GO:0097193
GO:0140297
GO:1904354
Ssc.8939.1.S2_at
Participates
as an input of
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Sus scrofa)
as a component of
MRN [nucleoplasm] (Sus scrofa)
as an output of
KPNA2 translocates NBN to the nucleus (Sus scrofa)
Other forms of this molecule
NBN [cytosol]
phospho-NBN [nucleoplasm]
Inferred From
NBN [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSSSCG00000006127
,
ENSSSCT00000035696
,
ENSSSCP00000029218
VGNC
90592
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