Reactome | CASP8 [cytosol]

CASP8 [cytosol]

Stable Identifier

R-SSC-75975

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

CASP8(217-374), Q56VC3

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-1 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - C-type lectin receptors (CLRs) (Sus scrofa)
    - CLEC7A (Dectin-1) signaling (Sus scrofa)
      - CLEC7A/inflammasome pathway (Sus scrofa)
        
        ASC binds Caspase-8 complex (Sus scrofa)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Sus scrofa)
        
        MALT1:active caspase-8 [cytosol] (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        MALT1:active caspase-8 [cytosol] (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        Caspase-8 binds MALT (Sus scrofa)
        
        MALT1:active caspase-8 [cytosol] (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        Caspase-8 cleaves IL1B precursor (Sus scrofa)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Sus scrofa)
        
        MALT1:active caspase-8 [cytosol] (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        TRIF-mediated programmed cell death (Sus scrofa)
        
        Caspase-8 processing within TLR4 complex (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Regulation of NF-kappa B signaling (Sus scrofa)
        
        CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)
        
        N4BP1 binds IKBKG (Sus scrofa)
        
        active caspase-8 [cytosol] (Sus scrofa)
        
        Caspase-8 dimer [cytosol] (Sus scrofa)
        
        CASP8 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q56VC3

Gene Names

CASP8

Reference Genes

BioGPS Gene:595105 CASP8

ENSEMBL:ENSSSCG00000028157.4

KEGG Gene (Sus scrofa):595105 CASP8

Monarch:595105 CASP8

NCBI Gene:595105 CASP8

Reference Transcript

RefSeq:NM_001031779.2 CASP8

Other Identifiers

595105

GO:0002376

GO:0003824

GO:0004197

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0006915

GO:0008233

GO:0008234

GO:0012501

GO:0016787

GO:0023052

GO:0030027

GO:0030154

GO:0030163

GO:0030335

GO:0031264

GO:0031265

GO:0031625

GO:0032731

GO:0032991

GO:0034612

GO:0035877

GO:0036462

GO:0042802

GO:0042981

GO:0043123

GO:0043124

GO:0043226

GO:0045651

GO:0045862

GO:0048856

GO:0048870

GO:0051603

GO:0051604

GO:0060546

GO:0071260

GO:0097110

GO:0097153

GO:0097190

GO:0097191

GO:0097194

GO:0097199

GO:0097342

GO:0140096

Ssc.31212.1.S1_at

Participates

as a component of

Caspase-8 dimer [cytosol] (Sus scrofa)

Other forms of this molecule

CASP8 [cytosol]

CASP8 [mitochondrial outer membrane]

CASP8 [cytosol]

Inferred From

CASP8(217-374) [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001026949.2

OpenTargets

ENSG00000064012

Ensembl

ENSSSCP00000026484, ENSSSCG00000028157, ENSSSCT00000024231

VGNC

95639

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