Reactome | phospho-POLR2A [nucleoplasm]

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA Pol II CTD phosphorylation and interaction with CE (Sus scrofa)
    - Activation of GT (Sus scrofa)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Pre-transcription Events (Sus scrofa)
    - Abortive termination of early transcription elongation by DSIF:NELF (Sus scrofa)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Transcription Elongation (Sus scrofa)
    - Formation of RNA Pol II elongation complex (Sus scrofa)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - Formation of the Early Elongation Complex (Sus scrofa)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
      - Formation of DSIF:NELF:early elongation complex (Sus scrofa)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Internal Methylation of mRNA (Sus scrofa)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
- mRNA Capping (Sus scrofa)
  - Activation of GT (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - Capping complex formation (Sus scrofa)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (initial) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - Dissociation of transcript with 5'-GMP from GT (Sus scrofa)
    - Capping complex (GpppN..) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - Formation of the CE:GMP intermediate complex (Sus scrofa)
    - Capping complex (intermediate) [nucleoplasm] (Sus scrofa)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Sus scrofa)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (hydrolyzed) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)
    - Capping complex (hydrolyzed) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (initial) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Sus scrofa)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)
    - Capping complex (intermediate) [nucleoplasm] (Sus scrofa)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Sus scrofa)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
    - Capping complex (GpppN..) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Nuclear Receptors (Sus scrofa)
  - ESR-mediated signaling (Sus scrofa)
    - Estrogen-dependent gene expression (Sus scrofa)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Sus scrofa)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        phospho-POLR2A [nucleoplasm] (Sus scrofa)