Reactome | CSF2RB [plasma membrane]

CSF2RB [plasma membrane]

Stable Identifier

R-SSC-879960

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

CSF2RB, A0A5G2QEJ3

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
      - Activation of STAT5a/b by JAK2 (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - GM-CSF receptor alpha:GM-CSF binds Bc (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - IL3RB is phosphorylated on Ser-585 (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - JAK2 is phosphorylated, activated (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - STAT5 is recruited by JAK2 (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - The receptor is activated (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - Tyrosine kinases phosphorylate the receptor (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
      - p-STAT5 dissociates from the receptor complex (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Sus scrofa)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Sus scrofa)
        
        CSF2RB [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QEJ3

Gene Names

CSF2RB

Reference Genes

ENSEMBL:ENSSSCG00000000136.5

Other Identifiers

100153254

GO:0004896

GO:0005515

GO:0005886

GO:0007259

GO:0015026

GO:0016020

GO:0023052

GO:0030526

GO:0038043

GO:0038156

GO:0038157

GO:0060089

GO:0070665

Ssc.28997.1.S1_at

Participates

as a component of

Other forms of this molecule

phospho-CSF2RB [plasma membrane]

Inferred From

CSF2RB [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000100368

Ensembl

ENSSSCT00000085649, ENSSSCG00000000136, ENSSSCP00000063095

VGNC

87033

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