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HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane]
Stable Identifier
R-SSC-8851943
Type
Set [DefinedSet]
Species
Sus scrofa
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by MET (Sus scrofa)
MET activates PI3K/AKT signaling (Sus scrofa)
MET bound PI3K generates PIP3 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
MET phosphorylates GAB1 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
MET activates PTPN11 (Sus scrofa)
GAB1 binds PTPN11 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
MET promotes cell motility (Sus scrofa)
MET activates RAP1 and RAC1 (Sus scrofa)
CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
DOCK7 activates RAC1 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GAB1 recruits CRK,CRKL to MET (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
RAPGEF1 activates RAP1 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
RAPGEF1 binds CRK,CRKL (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
MET receptor recycling (Sus scrofa)
GGA3 associates with activated MET receptor (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
Participants
members
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane]
(Sus scrofa)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane]
(Sus scrofa)
Participates
as an input of
GAB1 binds PTPN11 (Sus scrofa)
GAB1 recruits CRK,CRKL to MET (Sus scrofa)
Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)
as a component of
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
as an output of
MET phosphorylates GAB1 (Sus scrofa)
Inferred From
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane]
(Homo sapiens)
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