Reactome | phospho-EPS15 [cytosol]

phospho-EPS15 [cytosol]

Stable Identifier

R-SSC-8867028

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-Y849 EPS15, A0A5G2QFX7

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by EGFR (Sus scrofa)
    - EGFR downregulation (Sus scrofa)
      - EGFR phosphorylates EPS15 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PTPN3 dephosphorylates EPS15 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - Epsin family proteins bind ubiquitinated cargo (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - RAB5 and GAPVD1 bind AP-2 (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        p-Eps15:HGS:STAM [cytosol] (Sus scrofa)
        
        phospho-EPS15 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QFX7

Gene Names

EPS15

Reference Genes

ENSEMBL:ENSSSCG00000003872.5

Other Identifiers

100518076

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006895

GO:0006897

GO:0016192

GO:0016197

GO:0016235

GO:0019065

GO:0030132

GO:0031593

GO:0043226

GO:0043231

GO:0046718

GO:0046872

GO:0048268

GO:0065003

Participates

as a component of

p-Eps15:HGS:STAM [cytosol] (Sus scrofa)

Other forms of this molecule

EPS15 [cytosol]

Inferred From

p-Y849 EPS15 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine 849 replaced with unknown (in Homo sapiens)

Coordinate

849

PsiMod

O4'-phospho-L-tyrosine [MOD:00048]

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000085832

Ensembl

ENSSSCG00000003872, ENSSSCP00000060940, ENSSSCT00000077664

VGNC

87747

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