Reactome | phospho-CBL [cytosol]

phospho-CBL [cytosol]

Stable Identifier

R-SSC-8875457

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-Y-CBL, A0A286ZQE1

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by MET (Sus scrofa)
    - Negative regulation of MET activity (Sus scrofa)
      - CBL monoubiquitinates activated MET (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        p-Y-CBL:GRB2 [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        p-Y-CBL:GRB2 [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        p-Y-CBL:GRB2 [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        p-Y-CBL:GRB2 [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
      - EPS15 and HGS bind ubiquitinated MET (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        p-Y-CBL:GRB2 [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        p-Y-CBL:GRB2 [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
      - MET phosphorylates CBL (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        p-Y-CBL:GRB2 [cytosol] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Sus scrofa)
        
        phospho-CBL [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZQE1

Gene Names

CBL

Reference Genes

BioGPS Gene:100518854 CBL

ENSEMBL:ENSSSCG00000015115.5

KEGG:ssc:100518854 CBL

Monarch:100518854 CBL

NCBI Gene:100518854 CBL

UCSC:A0A286ZQE1 CBL

Reference Transcript

RefSeq:XM_003129932.3 CBL

Other Identifiers

100518854

GO:0001784

GO:0003824

GO:0004842

GO:0005509

GO:0005794

GO:0005829

GO:0005886

GO:0005929

GO:0006511

GO:0007165

GO:0007166

GO:0008152

GO:0012501

GO:0016192

GO:0016567

GO:0016600

GO:0016740

GO:0017124

GO:0023051

GO:0023052

GO:0030163

GO:0030971

GO:0032487

GO:0036211

GO:0042059

GO:0043066

GO:0043226

GO:0045121

GO:0046872

GO:0046875

GO:0048260

GO:0051897

GO:0061630

GO:0070086

GO:0140096

GO:2000583

Ssc.14185.1.A1_at

Ssc.1914.1.S1_at

Ssc.24231.1.S1_at

Ssc.24231.2.S1_at

Ssc.30540.1.A1_at

Participates

as a component of

as a member of

FLT3 ubiquitin ligases [cytosol] (Sus scrofa)

Other forms of this molecule

phospho-CBL [cytosol]

phospho-CBL [plasma membrane]

phospho-CBL [cytosol]

CBL [cytosol]

Inferred From

p-Y-CBL [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_003129980.1

ENSEMBL

ENSSSCG00000015115, ENSSSCT00000040411, ENSSSCP00000033673

VGNC

86222

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