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RAPGEF1 [cytosol]
Stable Identifier
R-SSC-913472
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
RAPGEF1, F1S0W0
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
Regulation of signaling by CBL (Sus scrofa)
CBL:CRKL binds RAPGEF1 (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Erythropoietin (Sus scrofa)
Erythropoietin activates RAS (Sus scrofa)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Sus scrofa)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
p-CRKL:RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Sus scrofa)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Sus scrofa)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
p-CRKL:RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by MET (Sus scrofa)
MET promotes cell motility (Sus scrofa)
MET activates RAP1 and RAC1 (Sus scrofa)
RAPGEF1 activates RAP1 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 binds CRK,CRKL (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK1 (TRKA) (Sus scrofa)
Signalling to ERKs (Sus scrofa)
Prolonged ERK activation events (Sus scrofa)
Frs2-mediated activation (Sus scrofa)
p-FRS2:CRKL binds C3G (Sus scrofa)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
Signaling by PDGF (Sus scrofa)
Downstream signal transduction (Sus scrofa)
p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase cycle (Sus scrofa)
RAC3 GTPase cycle (Sus scrofa)
RAC3 binds effectors at the plasma membrane (Sus scrofa)
RAC3 effectors [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
RAC3:GTP:RAC3 effectors [plasma membrane] (Sus scrofa)
RAC3 effectors [cytosol] (Sus scrofa)
RAPGEF1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1S0W0
Gene Names
RAPGEF1
Reference Genes
ENSEMBL:ENSSSCG00000005719.5
Other Identifiers
100511735
GO:0001568
GO:0005085
GO:0005886
GO:0007155
GO:0007264
GO:0007265
GO:0023052
GO:0043226
GO:0043231
GO:0043491
GO:0046580
GO:0048008
GO:0048856
GO:0051898
GO:0060070
GO:0061351
GO:0070371
GO:0070373
GO:0090090
GO:0098609
GO:0098772
GO:2000178
Ssc.31201.1.S1_at
Ssc.3567.1.S1_at
Participates
as a component of
p-CRKL:RAPGEF1 [cytosol] (Sus scrofa)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Sus scrofa)
as a candidate of
RAC3 effectors [cytosol] (Sus scrofa)
as an input of
CBL:CRKL binds RAPGEF1 (Sus scrofa)
p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)
RAPGEF1 binds CRK,CRKL (Sus scrofa)
p-FRS2:CRKL binds C3G (Sus scrofa)
Inferred From
RAPGEF1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000107263
Ensembl
ENSSSCP00000006127
,
ENSSSCG00000005719
,
ENSSSCT00000006289
VGNC
92091
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