Reactome | HBEGF [clathrin-coated endocytic vesicle membrane]

HBEGF [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-SSC-9628819

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

HBEGF(63-148), Q01580

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - RAB5 and GAPVD1 bind AP-2 (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        HBEGF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q01580

Gene Names

HBEGF

Reference Genes

BioGPS Gene:397564 HBEGF

ENSEMBL:ENSSSCG00000014362.5 HBEGF

ENSEMBL:ENSSSCG00015004214.1 HBEGF

ENSEMBL:ENSSSCG00025047977.1 HBEGF

ENSEMBL:ENSSSCG00030032732.1 HBEGF

ENSEMBL:ENSSSCG00035075778.1 HBEGF

ENSEMBL:ENSSSCG00040062792.1 HBEGF

ENSEMBL:ENSSSCG00055003344.1 HBEGF

ENSEMBL:ENSSSCG00060010975.1 HBEGF

ENSEMBL:ENSSSCG00065051871.1 HBEGF

ENSEMBL:ENSSSCG00070000111.1

KEGG Gene (Sus scrofa):397564 HBEGF

Monarch:397564 HBEGF

NCBI Gene:397564 HBEGF

Reference Transcript

RefSeq:NM_214299.1 HBEGF

Other Identifiers

397564

GO:0003013

GO:0005154

GO:0005576

GO:0005615

GO:0005886

GO:0007173

GO:0008016

GO:0008083

GO:0008201

GO:0008284

GO:0009986

GO:0016477

GO:0023052

GO:0030297

GO:0030335

GO:0035313

GO:0036211

GO:0038134

GO:0038135

GO:0042060

GO:0048018

GO:0048661

GO:0048856

GO:0048870

GO:0050731

GO:0051549

GO:0051897

GO:0060326

GO:0090303

GO:0098772

Ssc.16376.1.S1_at

Participates

as a member of

EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Other forms of this molecule

HBEGF [plasma membrane]

HBEGF [extracellular region]

Inferred From

HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_999464.1

OpenTargets

ENSG00000113070

Ensembl

ENSSSCT00000015692, ENSSSCP00000015279, ENSSSCG00000014362

VGNC

88792

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