Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p21 RAS:GTP [plasma membrane]
Stable Identifier
R-XTR-109783
Type
Complex
Species
Xenopus tropicalis
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Developmental Biology (Xenopus tropicalis)
Nervous system development (Xenopus tropicalis)
Axon guidance (Xenopus tropicalis)
NCAM signaling for neurite out-growth (Xenopus tropicalis)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Hemostasis (Xenopus tropicalis)
Cell surface interactions at the vascular wall (Xenopus tropicalis)
Tie2 Signaling (Xenopus tropicalis)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Signaling by the B Cell Receptor (BCR) (Xenopus tropicalis)
Downstream signaling events of B Cell Receptor (BCR) (Xenopus tropicalis)
Activation of RAS in B cells (Xenopus tropicalis)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Cytokine Signaling in Immune system (Xenopus tropicalis)
FLT3 Signaling (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
C-type lectin receptors (CLRs) (Xenopus tropicalis)
CD209 (DC-SIGN) signaling (Xenopus tropicalis)
PAK phosphorylates p21 RAF1 on S338 (Xenopus tropicalis)
p21 RAS:GTP:RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:p-S338-RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
RAF1 binds p21 RAS:GTP (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)
p21 RAS:GTP:p-S338,Y340,Y341-RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:p-S338-RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
DAP12 interactions (Xenopus tropicalis)
DAP12 signaling (Xenopus tropicalis)
SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
FCERI mediated MAPK activation (Xenopus tropicalis)
SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
Intrinsic nucleotide exchange on RAS (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Negative regulation of MAPK pathway (Xenopus tropicalis)
BRAP autoubiquitinates (Xenopus tropicalis)
p21 RAS:GTP:BRAP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:ub-BRAP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
BRAP binds RAS:GTP (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:BRAP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
PEBP1 binds activated RAF1 (Xenopus tropicalis)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
RAS:GTP binds PI3K (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:PI3K [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (q) signalling events (Xenopus tropicalis)
Gastrin-CREB signalling pathway via PKC and MAPK (Xenopus tropicalis)
EGFR Transactivation by Gastrin (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by Non-Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by PTK6 (Xenopus tropicalis)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Xenopus tropicalis)
RASA1 binds RAS:GTP (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:RASA1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)
p21 RAS:GTP:RASA1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by EGFR (Xenopus tropicalis)
GRB2 events in EGFR signaling (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
SHC1 events in EGFR signaling (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by ERBB2 (Xenopus tropicalis)
GRB2 events in ERBB2 signaling (Xenopus tropicalis)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by ERBB4 (Xenopus tropicalis)
SHC1 events in ERBB4 signaling (Xenopus tropicalis)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by FGFR (Xenopus tropicalis)
Signaling by FGFR1 (Xenopus tropicalis)
Downstream signaling of activated FGFR1 (Xenopus tropicalis)
FRS-mediated FGFR1 signaling (Xenopus tropicalis)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
SHC-mediated cascade:FGFR1 (Xenopus tropicalis)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by FGFR2 (Xenopus tropicalis)
Downstream signaling of activated FGFR2 (Xenopus tropicalis)
FRS-mediated FGFR2 signaling (Xenopus tropicalis)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
SHC-mediated cascade:FGFR2 (Xenopus tropicalis)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by FGFR3 (Xenopus tropicalis)
Downstream signaling of activated FGFR3 (Xenopus tropicalis)
FRS-mediated FGFR3 signaling (Xenopus tropicalis)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
SHC-mediated cascade:FGFR3 (Xenopus tropicalis)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by FGFR4 (Xenopus tropicalis)
Downstream signaling of activated FGFR4 (Xenopus tropicalis)
FRS-mediated FGFR4 signaling (Xenopus tropicalis)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
SHC-mediated cascade:FGFR4 (Xenopus tropicalis)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by MET (Xenopus tropicalis)
MET activates RAS signaling (Xenopus tropicalis)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
Signalling to ERKs (Xenopus tropicalis)
Signalling to RAS (Xenopus tropicalis)
p38MAPK events (Xenopus tropicalis)
Ral-GDS binds to Ras-GTP (Xenopus tropicalis)
Ras-GTP:RalGDS complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by PDGF (Xenopus tropicalis)
Downstream signal transduction (Xenopus tropicalis)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
Signaling by SCF-KIT (Xenopus tropicalis)
Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)
p21 RAS:GTP [plasma membrane] (Xenopus tropicalis)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Ghost homologue of mature p21 RAS [plasma membrane]
(Xenopus tropicalis)
GTP [cytosol]
Participates
as a component of
RASA1:p21 RAS:GTP:SPG [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:BRAP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:ub-BRAP [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:PI3K [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:RASA1 [plasma membrane] (Xenopus tropicalis)
Ras-GTP:RalGDS complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:p-S338-RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:p-S338,Y340,Y341-RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:RAF1 [plasma membrane] (Xenopus tropicalis)
as an input of
RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Xenopus tropicalis)
BRAP binds RAS:GTP (Xenopus tropicalis)
RAS:GTP binds PI3K (Xenopus tropicalis)
RASA1 binds RAS:GTP (Xenopus tropicalis)
Ral-GDS binds to Ras-GTP (Xenopus tropicalis)
RAF1 binds p21 RAS:GTP (Xenopus tropicalis)
as an output of
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)
RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)
Intrinsic nucleotide exchange on RAS (Xenopus tropicalis)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)
Inferred From
p21 RAS:GTP [plasma membrane]
(Homo sapiens)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
