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EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
Stable Identifier
R-XTR-1306961
Type
Complex
Species
Xenopus tropicalis
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
Intracellular signaling by second messengers (Xenopus tropicalis)
PIP3 activates AKT signaling (Xenopus tropicalis)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ERBB2 (Xenopus tropicalis)
PI3K events in ERBB2 signaling (Xenopus tropicalis)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane]
(Xenopus tropicalis)
pik3ca [cytosol]
(Xenopus tropicalis)
Participates
as an output of
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
as a member of
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
Inferred From
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
(Homo sapiens)
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