Reactome | sp1 [nucleoplasm]

sp1 [nucleoplasm]

Stable Identifier

R-XTR-1592223

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

SP1, F6VY28

Locations in the PathwayBrowser

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Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - RNA polymerase II transcribes snRNA genes (Xenopus tropicalis)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Xenopus tropicalis)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
    - Integrator complex processes the 3' end of snRNA (Xenopus tropicalis)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Xenopus tropicalis)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Xenopus tropicalis)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Xenopus tropicalis)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Xenopus tropicalis)
        
        sp1 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6VY28

Gene Names

sp1

Reference Genes

BioGPS Gene:394744 sp1

ENSEMBL:ENSXETG00000006274

ENSEMBL:ENSXETG00000012660 sp1

Monarch:394744 sp1

NCBI Gene:394744 sp1

Reference Transcript

RefSeq:XM_012956652.2 sp1

Other Identifiers

394744

Participates

as an input of

HATs and coactivators are recruited to the CTSD gene (Xenopus tropicalis)

as a component of

Inferred From

SP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_012812106.1

Ensembl

ENSXETT00000027712, ENSXETG00000012660, ENSXETP00000027712

Xenbase

XB-GENE-853336

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